Transcriptional Regulation in Saccharomyces Cerevisiae: Transcription Factor Regulation and Function, Mechanisms of Initiation, and Roles of Activators and Coactivators

Overview

Journal Genetics

Publisher Oxford University Press

Specialty Genetics

Date 2011 Nov 16

PMID 22084422

Citations 180

Authors

Steven Hahn

Elton T Young

Affiliations

Soon will be listed here.

Abstract

Here we review recent advances in understanding the regulation of mRNA synthesis in Saccharomyces cerevisiae. Many fundamental gene regulatory mechanisms have been conserved in all eukaryotes, and budding yeast has been at the forefront in the discovery and dissection of these conserved mechanisms. Topics covered include upstream activation sequence and promoter structure, transcription factor classification, and examples of regulated transcription factor activity. We also examine advances in understanding the RNA polymerase II transcription machinery, conserved coactivator complexes, transcription activation domains, and the cooperation of these factors in gene regulatory mechanisms.

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