Chicken Acidic Leucine-rich EGF-like Domain Containing Brain Protein (CALEB), a Neural Member of the EGF Family of Differentiation Factors, is Implicated in Neurite Formation

Overview

Journal J Cell Biol

Specialty Cell Biology

Date 1997 Feb 24

PMID 9049254

Citations 13

Authors

S Schumacher

H Volkmer

F Buck

A Otto

A Tarnok

S Roth

F G Rathjen

Affiliations

Soon will be listed here.

Abstract

Chicken acidic leucine-rich EGF-like domain containing brain protein (CALEB) was identified by combining binding assays with immunological screens in the chicken nervous system as a novel member of the EGF family of differentiation factors. cDNA cloning indicates that CALEB is a multidomain protein that consists of an NH2-terminal glycosylation region, a leucine-proline-rich segment, an acidic box, a single EGF-like domain, a transmembrane, and a short cytoplasmic stretch. In the developing nervous system, CALEB is associated with glial and neuronal surfaces. CALEB is composed of a 140/130-kD doublet, an 80-kD band, and a chondroitinsulfate-containing 200-kD component. The latter two components are expressed in the embryonic nervous system and are downregulated in the adult nervous system. CALEB binds to the extracellular matrix glycoproteins tenascin-C and -R. In vitro antibody perturbation experiments reveal a participation of CALEB in neurite formation in a permissive environment.

Citing Articles

Neurotrophic Factors and Dendritic Spines.

von Bohlen Und Halbach O Adv Neurobiol. 2023; 34:223-254.

PMID: 37962797 DOI: 10.1007/978-3-031-36159-3_5.

Early Days of Tenascin-R Research: Two Approaches Discovered and Shed Light on Tenascin-R.

Rathjen F, Hodge R Front Immunol. 2021; 11:612482.

PMID: 33488619 PMC: 7820773. DOI: 10.3389/fimmu.2020.612482.

The Role of Chondroitin Sulfate Proteoglycans in Nervous System Development.

Mencio C, Hussein R, Yu P, Geller H J Histochem Cytochem. 2020; 69(1):61-80.

PMID: 32936033 PMC: 7780190. DOI: 10.1369/0022155420959147.

Retinal pigment epithelium protein of 65 kDA gene-linked retinal degeneration is not modulated by chicken acidic leucine-rich epidermal growth factor-like domain containing brain protein/Neuroglycan C/ chondroitin sulfate proteoglycan 5.

Cottet S, Juttner R, Voirol N, Chambon P, Rathjen F, Schorderet D Mol Vis. 2013; 19:2312-20.

PMID: 24265546 PMC: 3834887.

Neuroglycan C, a brain-specific chondroitin sulfate proteoglycan, interacts with pleiotrophin, a heparin-binding growth factor.

Nakanishi K, Tokita Y, Aono S, Ida M, Matsui F, Higashi Y Neurochem Res. 2010; 35(8):1131-7.

PMID: 20369290 DOI: 10.1007/s11064-010-0164-9.

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