The Role of Chondroitin Sulfate Proteoglycans in Nervous System Development

Overview

Journal J Histochem Cytochem

Publisher Sage Publications

Specialty Biochemistry

Date 2020 Sep 16

PMID 32936033

Citations 22

Authors

Caitlin P Mencio

Rowan K Hussein

Panpan Yu

Herbert M Geller

Affiliations

Soon will be listed here.

Abstract

The orderly development of the nervous system is characterized by phases of cell proliferation and differentiation, neural migration, axonal outgrowth and synapse formation, and stabilization. Each of these processes is a result of the modulation of genetic programs by extracellular cues. In particular, chondroitin sulfate proteoglycans (CSPGs) have been found to be involved in almost every aspect of this well-orchestrated yet delicate process. The evidence of their involvement is complex, often contradictory, and lacking in mechanistic clarity; however, it remains obvious that CSPGs are key cogs in building a functional brain. This review focuses on current knowledge of the role of CSPGs in each of the major stages of neural development with emphasis on areas requiring further investigation.

Citing Articles

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Solid-Phase-Supported Chemoenzymatic Synthesis and Analysis of Chondroitin Sulfate Proteoglycan Glycopeptides.

Lin P, Xu Y, Bali S, Kim J, Gimeno A, Roberts E Angew Chem Int Ed Engl. 2024; 63(34):e202405671.

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Investigation of a chondroitin sulfate-based bioactive coating for neural interface applications.

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Glycosaminoglycan microarrays for studying glycosaminoglycan-protein systems.

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Developmental patterns of extracellular matrix molecules in the embryonic and postnatal mouse hindbrain.

Weber I, Dakos A, Meszar Z, Matesz C, Birinyi A Front Neuroanat. 2024; 18:1369103.

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