Impact of Photobiomodulation on IL1β and TGFβ-1 Concentrations in Patients with Aphthous Stomatitis

Overview

Journal Lasers Med Sci

Publisher Springer

Date 2024 Jul 8

PMID 38976032

Authors

Dalia Saleem Kareem

Layla M H Al-Ameri

Ammar Saleh AlAlawi

Affiliations

Soon will be listed here.

Abstract

Laser therapy has shown effectiveness in promoting wound healing by influencing various physiological factors such as blood flow, cytokines, histamine, nerve signals, lymphocyte function, tissue oxygenation, and cell growth. This study aims to evaluate the therapeutic efficacy of Photobiomodulation (PBM) treatment, by using diode laser, in modifying the levels of interleukin-1 beta (IL1β) and transforming growth factor beta-1 (TGFβ-1) in patients diagnosed with aphthous stomatitis. A before-after interventional design was conducted over 10 months with 20 subjects. Data on demographic details and serum concentrations of IL1β and TGFβ-1 were collected pre-treatment and on Days 3 and 7 post-treatments. The intervention involved a single session of four 30-second applications of a QuickLase dual-wavelength laser operating at 980 nm. Results show significant reductions in IL1β and TGFβ-1 levels after 7 days of treatment, indicating a time-dependent effect of PBM therapy on these inflammatory markers. The findings suggest that PBM therapy holds promise as an intervention for reducing inflammation associated with aphthous stomatitis.

References

Porter S, Hegarty A, Kaliakatsou F, Hodgson T, Scully C . Recurrent aphthous stomatitis. Clin Dermatol. 2001; 18(5):569-78. DOI: 10.1016/s0738-081x(00)00147-4. View

Pestka S, Krause C, Sarkar D, Walter M, Shi Y, Fisher P . Interleukin-10 and related cytokines and receptors. Annu Rev Immunol. 2004; 22:929-79. DOI: 10.1146/annurev.immunol.22.012703.104622. View

Turner D, Williams D, Sankaran D, Lazarus M, Sinnott P, Hutchinson I . An investigation of polymorphism in the interleukin-10 gene promoter. Eur J Immunogenet. 1997; 24(1):1-8. DOI: 10.1111/j.1365-2370.1997.tb00001.x. View

Sabat R . IL-10 family of cytokines. Cytokine Growth Factor Rev. 2010; 21(5):315-24. DOI: 10.1016/j.cytogfr.2010.11.001. View

Kang J, Lee M, Copland 3rd J, Luxon B, Gorenstein D . Combinatorial selection of a single stranded DNA thioaptamer targeting TGF-beta1 protein. Bioorg Med Chem Lett. 2008; 18(6):1835-9. PMC: 2323357. DOI: 10.1016/j.bmcl.2008.02.023. View

Field E, Allan R . Review article: oral ulceration--aetiopathogenesis, clinical diagnosis and management in the gastrointestinal clinic. Aliment Pharmacol Ther. 2003; 18(10):949-62. DOI: 10.1046/j.1365-2036.2003.01782.x. View

Al-Karadaghi T, Gutknecht N, Jawad H, Vanweersch L, Franzen R . Evaluation of Temperature Elevation During Root Canal Treatment with Dual Wavelength Laser: 2780 nm Er,Cr:YSGG and 940 nm Diode. Photomed Laser Surg. 2015; 33(9):460-6. DOI: 10.1089/pho.2015.3907. View

Al-Karadaghi T, Franzen R, Jawad H, Gutknecht N . Investigations of radicular dentin permeability and ultrastructural changes after irradiation with Er,Cr:YSGG laser and dual wavelength (2780 and 940 nm) laser. Lasers Med Sci. 2015; 30(8):2115-21. DOI: 10.1007/s10103-015-1757-y. View

Adhiah A, Al-Ameri L, Maki A, Wang Q, ALQaisi M . Modulating Heat Shock Proteins 70 and 90 Expression by Low Power Laser Irradiation (635nm and 780nm) in Jurkat E6.1 T-lymphocyte Leukemia Cell Line. J Lasers Med Sci. 2015; 6(1):17-21. PMC: 4329137. View

10.

Pereira L, Chimello D, Wimmers Ferreira M, Bachmann L, Rosa A, Bombonato-Prado K . Low-level laser therapy influences mouse odontoblast-like cell response in vitro. Photomed Laser Surg. 2012; 30(4):206-13. DOI: 10.1089/pho.2011.3087. View

11.

Safavi S, Kazemi B, Esmaeili M, Fallah A, Modarresi A, Mir M . Effects of low-level He-Ne laser irradiation on the gene expression of IL-1beta, TNF-alpha, IFN-gamma, TGF-beta, bFGF, and PDGF in rat's gingiva. Lasers Med Sci. 2007; 23(3):331-5. DOI: 10.1007/s10103-007-0491-5. View

12.

Oton-Leite A, Silva G, Morais M, Silva T, Leles C, Valadares M . Effect of low-level laser therapy on chemoradiotherapy-induced oral mucositis and salivary inflammatory mediators in head and neck cancer patients. Lasers Surg Med. 2015; 47(4):296-305. DOI: 10.1002/lsm.22349. View

13.

Mesquita-Ferrari R, Martins M, Silva Jr J, da Silva T, Piovesan R, Pavesi V . Effects of low-level laser therapy on expression of TNF-α and TGF-β in skeletal muscle during the repair process. Lasers Med Sci. 2010; 26(3):335-40. DOI: 10.1007/s10103-010-0850-5. View

14.

Singer A, Clark R . Cutaneous wound healing. N Engl J Med. 1999; 341(10):738-46. DOI: 10.1056/NEJM199909023411006. View

15.

Morikawa M, Derynck R, Miyazono K . TGF-β and the TGF-β Family: Context-Dependent Roles in Cell and Tissue Physiology. Cold Spring Harb Perspect Biol. 2016; 8(5). PMC: 4852809. DOI: 10.1101/cshperspect.a021873. View

16.

Massague J . TGFβ signalling in context. Nat Rev Mol Cell Biol. 2012; 13(10):616-30. PMC: 4027049. DOI: 10.1038/nrm3434. View

17.

Murphy-Ullrich J, Poczatek M . Activation of latent TGF-beta by thrombospondin-1: mechanisms and physiology. Cytokine Growth Factor Rev. 2000; 11(1-2):59-69. DOI: 10.1016/s1359-6101(99)00029-5. View

18.

Maligieri L, Neves L, de Morais D, Domingues R, de Aro A, Pimentel E . Differing energy densities with laser 670nm InGaP controls inflammation and collagen reorganization in burns. Burns. 2017; 43(7):1524-1531. DOI: 10.1016/j.burns.2017.04.008. View

19.

Turkucar S, Bulbul G, Unsal E, Ozer E, Erdag T, Erkoc E . Exploring the immunological basis of periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome: immunohistochemical staining features of palatine tonsils. Clin Rheumatol. 2023; 42(7):1911-1916. DOI: 10.1007/s10067-023-06563-2. View

20.

Chiang C, Yu-Fong Chang J, Wang Y, Wu Y, Wu Y, Sun A . Recurrent aphthous stomatitis - Etiology, serum autoantibodies, anemia, hematinic deficiencies, and management. J Formos Med Assoc. 2018; 118(9):1279-1289. DOI: 10.1016/j.jfma.2018.10.023. View