Ishophloroglucin A, a Novel Phlorotannin for Standardizing the Anti-α-Glucosidase Activity of

Overview

Journal Mar Drugs

Publisher MDPI

Specialties Biology
Pharmacology

Date 2018 Nov 11

PMID 30413003

Citations 19

Authors

Bomi Ryu

Yunfei Jiang

Hyun-Soo Kim

Jee-Min Hyun

Sang-Bin Lim

Yong Li

You-Jin Jeon

Affiliations

Soon will be listed here.

Abstract

Nutraceutical use of algae requires understanding of the diversity and significance of their active compositions for intended activities. () extract is well-known to possess α-glucosidase inhibitory activity; however, studies are needed to investigate its active composition in order to standardize its α-glucosidase inhibitory activity. In this study, we observed the intensity of the dominant compounds of each extract harvested between 2016 and 2017, and the different potency of each extract against α-glucosidase. By comparing the anti-α-glucosidase ability of the dominant compounds, a novel Ishophloroglucin A with highest α-glucosidase inhibitory activity was identified and suggested for standardization of anti-α-glucosidase activity in extract. Additionally, a validated analytical method for measurement of Ishophloroglucin A for future standardization of extract was established in this study. We suggest using Ishophloroglucin A to standardize anti-α-glucosidase potency of and propose the significance of standardization based on their composition for effective use of algae as marine-derived nutraceuticals.

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