Annexin V Autoantibodies in Rheumatoid Arthritis

Overview

Journal Ann Rheum Dis

Specialty Rheumatology

Date 1996 Dec 1

PMID 9014583

Citations 14

Authors

M I Rodriguez-Garcia

J A Fernandez

A Rodriguez

M P Fernandez

C Gutierrez

J C Torre-Alonso

Affiliations

Soon will be listed here.

Abstract

Objective: To investigate the occurrence of anti-annexin V autoantibodies in sera of patients with rheumatoid arthritis to assess involvement with the disease and any relation to glucocorticoid treatment.

Methods: Anti-annexin V antibodies were measured by an enzyme linked immunosorbent assay (ELISA) which used the purified human recombinant protein as antigen.

Results: Concentrations of anti-annexin V autoantibodies, predominantly of the IgG class, were significantly raised in sera from patients with rheumatoid arthritis compared to normal controls. This was not correlated with other indices of disease activity such as erythrocyte sedimentation rate or C reactive protein and was unrelated to glucocorticoid treatment.

Conclusions: Extracellular annexin V provides an antigenic stimulus for autoantibody production and its in vivo expression is independent of glucocorticoid control. Such autoantibodies may have a detrimental role in the arthritic condition by interfering with putative functions of annexin V, including collagen type II binding, inhibition of phospholipase A2 activity, and Fc receptor activity.

Citing Articles

A Temporal Comparative RNA Transcriptome Profile of the Annexin Gene Family in the Salivary versus Lacrimal Glands of the Sjögren's Syndrome-Susceptible C57BL/6.NOD- Mouse.

Peck A, Ambrus Jr J Int J Mol Sci. 2022; 23(19).

PMID: 36233010 PMC: 9570365. DOI: 10.3390/ijms231911709.

Annexin A1-dependent tethering promotes extracellular vesicle aggregation revealed with single-extracellular vesicle analysis.

Rogers M, Buffolo F, Schlotter F, Atkins S, Lee L, Halu A Sci Adv. 2020; 6(38).

PMID: 32938681 PMC: 7494353. DOI: 10.1126/sciadv.abb1244.

Biomarkers in Vasculitides of the Nervous System.

Strunk D, Schmidt-Pogoda A, Beuker C, Milles L, Korsukewitz C, Meuth S Front Neurol. 2019; 10:591.

PMID: 31244756 PMC: 6562258. DOI: 10.3389/fneur.2019.00591.

Annexins in Translational Research: Hidden Treasures to Be Found.

Schloer S, Pajonczyk D, Rescher U Int J Mol Sci. 2018; 19(6).

PMID: 29914106 PMC: 6032224. DOI: 10.3390/ijms19061781.

Time-dependent proteomic and genomic alterations in Toll-like receptor-4-activated human chondrocytes: increased expression of lamin A/C and annexins.

Ha S, Kim H, Anh N, Kim N, Ko K, Rhee B Korean J Physiol Pharmacol. 2017; 21(5):531-546.

PMID: 28883757 PMC: 5587603. DOI: 10.4196/kjpp.2017.21.5.531.

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