Impaired Glucocorticoid Induction of Mononuclear Leukocyte Lipocortin-1 in Rheumatoid Arthritis

Overview

Journal Arthritis Rheum

Specialty Rheumatology

Date 1994 Feb 1

PMID 8129776

Citations 9

Authors

E F Morand

C M Jefferiss

J Dixey

D Mitra

N J Goulding

Affiliations

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Abstract

Objective: To investigate leukocyte lipocortin-1 production in rheumatoid arthritis (RA).

Methods: Eight control and 8 RA subjects received 100 mg hydrocortisone intravenously. Leukocyte lipocortin-1 was measured by enzyme-linked immunosorbent assay.

Results: Hydrocortisone induced significant increases in lipocortin-1 production by control mononuclear cells (MNC) (P = 0.006 versus baseline) but not by RA MNC (P = 0.44 versus baseline). Peak lipocortin-1 levels in control MNC were significantly higher than those in RA MNC (P = 0.014).

Conclusion: These results indicate that glucocorticoid-induced MNC lipocortin-1 production is impaired in RA.

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