Interactions Between Human Serum Proteins and Oral Streptococci Reveal Occurrence of Receptors for Aggregated Beta 2-microglobulin

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 1979 Jul 1

PMID 90015

Citations 9

Authors

D Ericson

D Bratthall

L Bjorck

E Myhre

G Kronvall

Affiliations

Soon will be listed here.

Abstract

A total of 31 strains of oral streptococci representing Streptococcus mutans, Streptococcus sanguis, Streptococcus mitior, Streptococcus salivarius, and Streptococcus milleri were tested for possible binding of human immunoglobulins G, G1, G2, G3, G4, A1, A2, M1, and M2 and haptoglobin, hemoglobin, fibrinogen, and aggregated beta 2-microglobulin. Radiolabeled beta 2-microglobulin in aggregated form showed affinity for 20 of the 31 strains tested. Binding activity for the protein was found in strains belonging to all five species. The bacterial receptor was resistant to trypsin. Monomeric, unlabeled beta 2-microglobulin did not interfere with the binding of the aggregated form. Of the other proteins tested, only the immunoglobulin A1 protein showed positive binding, and that was only with a single strain of S. milleri. beta 2-Microglobulin is present on all nucleated cell membranes in vivo. The reaction between aggregated beta 2-microglobulin and oral streptococci is a new type of human-bacterium interaction which should be considered in studies of bacterial adherence.

Citing Articles

Examination of Streptococcus mutans for immunoglobulin G Fc reactivity.

Shea C, Ferretti J Infect Immun. 1981; 34(3):851-5.

PMID: 7333670 PMC: 350947. DOI: 10.1128/iai.34.3.851-855.1981.

Reaction of human colostral and early milk antibodies with oral streptococci.

Eggert F, GURNER B Infect Immun. 1984; 44(3):660-4.

PMID: 6427113 PMC: 263661. DOI: 10.1128/iai.44.3.660-664.1984.

Agglutination of Streptococcus mutans by low-molecular-weight salivary components: effect of beta 2-microglobulin.

Ericson D Infect Immun. 1984; 46(2):526-30.

PMID: 6389347 PMC: 261566. DOI: 10.1128/iai.46.2.526-530.1984.

Aggregation of Streptococcus sanguis by a neuraminidase-sensitive component of serum and crevicular fluid.

Morris E, McBride B Infect Immun. 1983; 42(3):1073-80.

PMID: 6358038 PMC: 264409. DOI: 10.1128/iai.42.3.1073-1080.1983.

Prevalence of anti-beta-2 microglobulin autoantibodies in sera of rheumatoid arthritis patients with extra-articular manifestations.

Falus A, Meretey K, Bozsoky S Ann Rheum Dis. 1981; 40(4):409-13.

PMID: 6167213 PMC: 1000738. DOI: 10.1136/ard.40.4.409.

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