Sclerotiamide: a New Member of the Paraherquamide Class with Potent Antiinsectan Activity from the Sclerotia of Aspergillus Sclerotiorum

Overview

Journal J Nat Prod

Date 1996 Nov 1

PMID 8946752

Citations 35

Authors

A C Whyte

J B Gloer

D T Wicklow

P F Dowdw

Affiliations

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Abstract

Sclerotiamide (1), a new fungal natural product related to the paraherquamides, was isolated by bioassay-guided fractionation of antiinsectan organic extracts from the sclerotia of Aspergillus sclerotiorum (NRRL 5167). The structure was determined primarily through 1H-NMR, 13C-NMR, HMQC, and HMBC experiments. Sclerotiamide causes significant mortality and unusual physiological effects in dietary assays against the corn earworm Helicoverpa zea.

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