Bioactive Indole Diketopiperazine Alkaloids from the Marine Endophytic Fungus Sp. YJ191021

Overview

Journal Mar Drugs

Publisher MDPI

Specialties Biology
Pharmacology

Date 2021 Apr 3

PMID 33802820

Citations 17

Authors

Jin Yang

Lizhi Gong

Miaomiao Guo

Yu Jiang

Yi Ding

Zhijie Wang

Xiujuan Xin

Faliang An

Affiliations

Soon will be listed here.

Abstract

Six new prenylated indole diketopiperazine alkaloids, asperthrins A-F (-), along with eight known analogues (-), were isolated from the marine-derived endophytic fungus sp. YJ191021. Their planar structures and absolute configurations were elucidated by HR-ESI-MS, 1D/2D NMR data, and time-dependent density functional theory (TDDFT)/ECD calculation. The isolated compounds were assayed for their inhibition against three agricultural pathogenic fungi, four fish pathogenic bacteria, and two agricultural pathogenic bacteria. Compound exhibited moderate antifungal and antibacterial activities against pv. , and with minimal inhibitory concentration (MIC) values of 8, 12.5, and 25 μg/mL, respectively. Furthermore, displayed notable anti-inflammatory activity with IC value of 1.46 ± 0.21 μM in induced human monocyte cell line (THP-1).

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