Cell Stress-regulated Human Major Histocompatibility Complex Class I Gene Expressed in Gastrointestinal Epithelium

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1996 Oct 29

PMID 8901601

Citations 323

Authors

V Groh

S Bahram

S Bauer

A Herman

M Beauchamp

T Spies

Affiliations

Soon will be listed here.

Abstract

Conventional major histocompatibility complex (MHC) class I genes encode molecules that present intracellular peptide antigens to T cells. They are ubiquitously expressed and regulated by interferon gamma. Two highly divergent human MHC class I genes, MICA and MICB, are regulated by promoter heat shock elements similar to those of HSP70 genes. MICA encodes a cell surface glycoprotein, which is not associated with beta 2-microglobulin, is conformationally stable independent of conventional class I peptide ligands, and almost exclusively expressed in gastrointestinal epithelium. Thus, this MHC class I molecule may function as an indicator of cell stress and may be recognized by a subset of gut mucosal T cells in an unusual interaction.

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