Hypothermia in Multiple Sclerosis

Overview

Journal J Neurol Neurosurg Psychiatry

Publisher BMJ Publishing Group

Specialties Neurology
Neurosurgery
Psychiatry

Date 1996 Oct 1

PMID 8890775

Citations 10

Authors

K D White

D J Scoones

P K Newman

Affiliations

Soon will be listed here.

Abstract

Five patients with clinically definite multiple sclerosis are reported who presented with acute relapses associated with hypothermia. Repeated episodes of hypothermia were seen in four. Thrombocytopenia was associated with the hypothermia in four patients. Further investigation disclosed a tendency to chronic hypothermia and suggested an altered thermoregulatory set point in one patient, when MRI, endocrine, and autonomic studies failed to localise a lesion in the hypothalamus, but subsequent necropsy showed hypothalamic lesions. In such patients a predisposition to altered thermoregulation may occur due to direct involvement of the hypothalamus or from combined lesions affecting hypothalamic outflow to the brainstem and spinal cord.

Citing Articles

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References

BROWNELL B, Hughes J . The distribution of plaques in the cerebrum in multiple sclerosis. J Neurol Neurosurg Psychiatry. 1962; 25:315-20. PMC: 495470. DOI: 10.1136/jnnp.25.4.315. View

JOSHI V, Chaudhuri A, Karnad D, Tilve G . Hypothermia due to transient hypothalamic dysfunction in tuberculous meningitis with hydrocephalus. Br J Neurosurg. 1992; 6(4):385-7. DOI: 10.3109/02688699209023801. View

Mann M, Degos J . [Hypothermia in Wernicke's encephalopathy]. Rev Neurol (Paris). 1987; 143(10):684-6. View

OBrien H, Amess J, MOLLIN D . Recurrent thrombocytopenia, erythroid hypoplasia and sideroblastic anaemia associated with hypothermia. Br J Haematol. 1982; 51(3):451-6. DOI: 10.1111/j.1365-2141.1982.tb02802.x. View

Shapiro W, Williams G, Plum F . Spontaneous recurrent hypothermia accompanying agenesis of the corpus callosum. Brain. 1969; 92(2):423-36. DOI: 10.1093/brain/92.2.423. View

CASTAIGNE P, ESCOUROLLE R, Laplane D, Augustin P . [Transient comas with hyperthermia in multiple sclerosis]. Rev Neurol (Paris). 1966; 114(2):147-50. View

Gordon C, Heath J . Integration and central processing in temperature regulation. Annu Rev Physiol. 1986; 48:595-612. DOI: 10.1146/annurev.ph.48.030186.003115. View

Nagashima T, Yamada K, UONO M, Nagashima K . Multiple sclerosis co-existent with myxedema. An autopsy case report. J Neurol Sci. 1984; 66(2-3):217-21. DOI: 10.1016/0022-510x(84)90010-8. View

Kurtzke J . FURTHER NOTES ON DISABILITY EVALUATION IN MULTIPLE SCLEROSIS, WITH SCALE MODIFICATIONS. Neurology. 1965; 15:654-61. DOI: 10.1212/wnl.15.7.654. View

10.

Mutani R, Clemente S, Lamberti A, Monaco F . Assessment of autonomic disturbances in multiple sclerosis by measurement of heart rate responses to deep breathing and to standing. Ital J Neurol Sci. 1982; 3(2):111-4. DOI: 10.1007/BF02043941. View

11.

Lammens M, Lissoir F, Carton H . Hypothermia in three patients with multiple sclerosis. Clin Neurol Neurosurg. 1989; 91(2):117-21. DOI: 10.1016/s0303-8467(89)80031-9. View

12.

Ghawche F, Destee A . [Hypothermia and multiple sclerosis. A case with 3 episodes of transient hypothermia]. Rev Neurol (Paris). 1990; 146(12):767-9. View

13.

Vita G, Fazio M, MILONE S, Blandino A, Salvi L, Messina C . Cardiovascular autonomic dysfunction in multiple sclerosis is likely related to brainstem lesions. J Neurol Sci. 1993; 120(1):82-6. DOI: 10.1016/0022-510x(93)90029-x. View

14.

Gilbert T, Blatteis C . Hypothalamic thermoregulatory pathways in the rat. J Appl Physiol Respir Environ Exerc Physiol. 1977; 43(5):770-7. DOI: 10.1152/jappl.1977.43.5.770. View

15.

Pledger H . Disorders of temperature regulation in acute traumatic tetraplegia. J Bone Joint Surg Br. 1962; 44-B:110-3. DOI: 10.1302/0301-620X.44B1.110. View

16.

Nogues M, Newman P, Male V, Foster J . Cardiovascular reflexes in syringomyelia. Brain. 1982; 105 (Pt 4):835-49. DOI: 10.1093/brain/105.4.835. View

17.

Hessel 2nd E, Schmer G, Dillard D . Platelet kinetics during deep hypothermia. J Surg Res. 1980; 28(1):23-34. DOI: 10.1016/0022-4804(80)90078-5. View

18.

Rohrer M, NATALE A . Effect of hypothermia on the coagulation cascade. Crit Care Med. 1992; 20(10):1402-5. DOI: 10.1097/00003246-199210000-00007. View

19.

Carr-Locke D, Millac P . Diencephalic epilepsy in a patient with agenesis of the corpus callosum confirmed by computerised axial tomography. J Neurol Neurosurg Psychiatry. 1977; 40(8):808-14. PMC: 492840. DOI: 10.1136/jnnp.40.8.808. View

20.

Johnson R, Delahunt J, Robinson B . Do thermoregulatory reflexes pass through the hypothalamus? Studies of chronic hypothermia due to hypothalamic lesion. Aust N Z J Med. 1990; 20(2):154-9. DOI: 10.1111/j.1445-5994.1990.tb01293.x. View