Cytotoxic Trichilin-type Limonoids from Melia Azedarach

Overview

Journal Bioorg Med Chem

Specialties Biochemistry
Chemistry

Date 1996 Aug 1

PMID 8879558

Citations 6

Authors

K Takeya

Z S Quio

C Hirobe

H Itokawa

Affiliations

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Abstract

Five new trichilin-type limonoids, named 12-deacetyltrichilin I (1), 1-acetyltrichilin H (2), 3-deacetyltrichilin H (3), 1-acetyl-3-deacetyltrichilin H (4), 1-acetyl-2-deacetyltrichilin H (5), together with four known trichilins, meliatoxin B1 (6), trichilin H (7), trichilin D (8) and 1,12-diacetyltrichilin B (9) were isolated from the extract of the root bark of Melia azedarach. The structures were elucidated by spectroscopic means and their cytotoxic activities against P388 cells in vitro were tested by means of MTT assay.

Citing Articles

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Highly Oxygenated Limonoids and Lignans from Phyllanthus flexuosus.

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The Toxicity and Anti-cancer Activity of the Hexane Layer of Melia azedarach L. var. japonica Makino's Bark Extract.

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