Epidermal Growth Factor Receptor and C-erbB-2 Expression in Normal Breast Tissue During the Menstrual Cycle

Overview

Journal Breast Cancer Res Treat

Specialty Oncology

Date 1996 Jan 1

PMID 8861841

Citations 12

Authors

A Gompel

A Martin

P Simon

D Schoevaert

G Plu-Bureau

D Hugol

J Audouin

E Leygue

J B Truc

P Poitout

Affiliations

Soon will be listed here.

Abstract

EGF receptor (EGF-R) and c-erbB-2 are homologous tyrosine kinase transmembrane receptors. They are involved in controlling proliferation, and probably differentiation, of normal breast epithelial cells, and their expression has been linked to the prognosis of breast cancer. Their physiological roles in normal breast tissue remain to be elucidated, as most studies to date have involved breast cancer cell lines. We studied the location of EGF-R and c-erbB-2 in 100 samples of normal breast with standard immunohistochemical methods and double-labelling techniques. EGF-R was mainly expressed on the stroma and myoepithelial cells, whereas c-erbB-2 expression was exclusively epithelial. An image analyser was used to quantitate variations in their expression during the menstrual cycle. EGF-R and c-erbB-2 expression on epithelial cells was stronger during the luteal phase than the follicular phase (p < 0.01 for EGF-R). The pattern of expression was also compared with that in 28 breast cancers and 7 fibroadenomas.

Citing Articles

Ovarian cycle stage critically affects 21-gene recurrence scores in Mmtv-Pymt mouse mammary tumours.

Bernhardt S, Dasari P, Glynn D, Woolford L, Moldenhauer L, Walsh D BMC Cancer. 2021; 21(1):736.

PMID: 34174867 PMC: 8236154. DOI: 10.1186/s12885-021-08496-y.

Discordance in 21-gene recurrence scores between paired breast cancer samples is inversely associated with patient age.

Bernhardt S, Dasari P, Wrin J, Raymond W, Edwards S, Walsh D Breast Cancer Res. 2020; 22(1):90.

PMID: 32811558 PMC: 7437067. DOI: 10.1186/s13058-020-01327-1.

Timing of breast cancer surgery during the menstrual cycle-is there an optimal time of the month?.

Bernhardt S, Dasari P, Walsh D, Townsend A, Price T, Ingman W Oncol Lett. 2020; 20(3):2045-2057.

PMID: 32782523 PMC: 7400969. DOI: 10.3892/ol.2020.11771.

A study of HER-2/neu expression and silver binding nucleolar organizer regions (Ag NORs) in perilesional normal salivary gland tissue.

Gaballah E Saudi Dent J. 2013; 22(2):89-94.

PMID: 23960481 PMC: 3723257. DOI: 10.1016/j.sdentj.2010.02.005.

The t10,c12 isomer of conjugated linoleic acid stimulates mammary tumorigenesis in transgenic mice over-expressing erbB2 in the mammary epithelium.

Ip M, McGee S, Masso-Welch P, Ip C, Meng X, Ou L Carcinogenesis. 2007; 28(6):1269-76.

PMID: 17259656 PMC: 2776704. DOI: 10.1093/carcin/bgm018.

References

Peles E, Bacus S, Koski R, Lu H, Wen D, Ogden S . Isolation of the neu/HER-2 stimulatory ligand: a 44 kd glycoprotein that induces differentiation of mammary tumor cells. Cell. 1992; 69(1):205-16. DOI: 10.1016/0092-8674(92)90131-u. View

Kraus M, Popescu N, Amsbaugh S, King C . Overexpression of the EGF receptor-related proto-oncogene erbB-2 in human mammary tumor cell lines by different molecular mechanisms. EMBO J. 1987; 6(3):605-10. PMC: 553440. DOI: 10.1002/j.1460-2075.1987.tb04797.x. View

Muller W, Sinn E, Pattengale P, Wallace R, Leder P . Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene. Cell. 1988; 54(1):105-15. DOI: 10.1016/0092-8674(88)90184-5. View

Dati C, Antoniotti S, Taverna D, Perroteau I, De Bortoli M . Inhibition of c-erbB-2 oncogene expression by estrogens in human breast cancer cells. Oncogene. 1990; 5(7):1001-6. View

Dickson R, Lippman M . Estrogenic regulation of growth and polypeptide growth factor secretion in human breast carcinoma. Endocr Rev. 1987; 8(1):29-43. DOI: 10.1210/edrv-8-1-29. View

Press M, Cordon-Cardo C, Slamon D . Expression of the HER-2/neu proto-oncogene in normal human adult and fetal tissues. Oncogene. 1990; 5(7):953-62. View

Velu T . Structure, function and transforming potential of the epidermal growth factor receptor. Mol Cell Endocrinol. 1990; 70(3):205-16. DOI: 10.1016/0303-7207(90)90211-p. View

Giudice L . Growth factors and growth modulators in human uterine endometrium: their potential relevance to reproductive medicine. Fertil Steril. 1994; 61(1):1-17. DOI: 10.1016/s0015-0282(16)56447-4. View

Kornilova E, Taverna D, Hoeck W, Hynes N . Surface expression of erbB-2 protein is post-transcriptionally regulated in mammary epithelial cells by epidermal growth factor and by the culture density. Oncogene. 1992; 7(3):511-9. View

10.

Damjanov I, Mildner B, Knowles B . Immunohistochemical localization of the epidermal growth factor receptor in normal human tissues. Lab Invest. 1986; 55(5):588-92. View

11.

Russell K, Hung M . Transcriptional repression of the neu protooncogene by estrogen stimulated estrogen receptor. Cancer Res. 1992; 52(23):6624-9. View

12.

PIERCE J, ARNSTEIN P, DIMARCO E, Artrip J, Kraus M, Lonardo F . Oncogenic potential of erbB-2 in human mammary epithelial cells. Oncogene. 1991; 6(7):1189-94. View

13.

Rotin D, Pinchasi D, Ullrich A, Schlessinger J, Lax I . Heterodimerization of c-erbB2 with different epidermal growth factor receptor mutants elicits stimulatory or inhibitory responses. J Biol Chem. 1992; 267(12):8056-63. View

14.

Longacre T, Bartow S . A correlative morphologic study of human breast and endometrium in the menstrual cycle. Am J Surg Pathol. 1986; 10(6):382-93. DOI: 10.1097/00000478-198606000-00003. View

15.

Slamon D, Clark G, Wong S, Levin W, Ullrich A, McGuire W . Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science. 1987; 235(4785):177-82. DOI: 10.1126/science.3798106. View

16.

Warri A, Laine A, Majasuo K, Alitalo K, Harkonen P . Estrogen suppression of erbB2 expression is associated with increased growth rate of ZR-75-1 human breast cancer cells in vitro and in nude mice. Int J Cancer. 1991; 49(4):616-23. DOI: 10.1002/ijc.2910490425. View

17.

Dougall W, Qian X, Greene M . Interaction of the neu/p185 and EGF receptor tyrosine kinases: implications for cellular transformation and tumor therapy. J Cell Biochem. 1993; 53(1):61-73. DOI: 10.1002/jcb.240530108. View

18.

Bacus S, Kiguchi K, Chin D, King C, Huberman E . Differentiation of cultured human breast cancer cells (AU-565 and MCF-7) associated with loss of cell surface HER-2/neu antigen. Mol Carcinog. 1990; 3(6):350-62. DOI: 10.1002/mc.2940030607. View

19.

Derynck R . Transforming growth factor alpha. Cell. 1988; 54(5):593-5. DOI: 10.1016/s0092-8674(88)80001-1. View

20.

Ferguson D, Anderson T . Morphological evaluation of cell turnover in relation to the menstrual cycle in the "resting" human breast. Br J Cancer. 1981; 44(2):177-81. PMC: 2010743. DOI: 10.1038/bjc.1981.168. View