Tissue Architecture and Breast Cancer: the Role of Extracellular Matrix and Steroid Hormones

Overview

Journal Endocr Relat Cancer

Specialties Endocrinology
Oncology

Date 2000 Jul 21

PMID 10903527

Citations 29

Authors

R K Hansen

M J Bissell

Affiliations

Soon will be listed here.

Abstract

The changes in tissue architecture that accompany the development of breast cancer have been the focus of investigations aimed at developing new cancer therapeutics. As we learn more about the normal mammary gland, we have begun to understand the complex signaling pathways underlying the dramatic shifts in the structure and function of breast tissue. Integrin-, growth factor-, and steroid hormone-signaling pathways all play an important part in maintaining tissue architecture; disruption of the delicate balance of signaling results in dramatic changes in the way cells interact with each other and with the extracellular matrix, leading to breast cancer. The extracellular matrix itself plays a central role in coordinating these signaling processes. In this review, we consider the interrelationships between the extracellular matrix, integrins, growth factors, and steroid hormones in mammary gland development and function.

Citing Articles

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