Down-regulation of Na Channel Expression by A23187 in N1E-115 Neuroblastoma Cells

Overview

Journal Brain Res

Specialty Neurology

Date 1996 Jan 15

PMID 8822380

Citations 7

Authors

J K Hirsh

F N Quandt

Affiliations

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Abstract

Growth of cultured N1E-115 neuroblastoma cells in 1 microM A23187 for 2 days to elevate internal Ca reduced both membrane Na current and the transient, but not steady state, component of outward K current. Na channel mRNA abundance was reduced by an average value of 45% without effect on Kv3.1. Increases in internal Ca may therefore control excitability by independent regulation of Na and K channel mRNA abundance in neurons.

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