The Protein Phosphatase 2C (PP2C) Superfamily: Detection of Bacterial Homologues

Overview

Journal Protein Sci

Specialty Biochemistry

Date 1996 Jul 1

PMID 8819174

Citations 73

Authors

P Bork

N P Brown

H Hegyi

J Schultz

Affiliations

Soon will be listed here.

Abstract

A thorough sequence analysis of the various members of the eukaryotic protein serine/threonine phosphatase 2C (PP2C) family revealed the conservation of 11 motifs. These motifs could be identified in numerous other sequences, including fungal adenylate cyclases that are predicted to contain a functionally active PP2C domain, and a family of prokaryotic serine/threonine phosphatases including SpoIIE. Phylogenetic analysis of all the proteins indicates a widespread sequence family for which a considerable number of isoenzymes can be inferred.

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