Inhibition of MAO-B by (-)-deprenyl Alters Dopamine Metabolism in the Macaque (Macaca Facicularis) Brain

Overview

Journal Neurochem Res

Specialties Chemistry
Neurology

Date 1995 Dec 1

PMID 8789614

Citations 4

Authors

I A Paterson

B A Davis

D A Durden

A V Juorio

P H Yu

G Ivy

W Milgram

A Mendonca

P Wu

A A Boulton

Affiliations

Soon will be listed here.

Abstract

The present study has examined whether MAO-B has a role in DA metabolism in the primate CNS in situ. Eleven macaques (macaca facicularis) were used in this study to examine the effects of (-)-deprenyl (1 mg/kg, i.v., 2 and 24 hours). (-)-Deprenyl administration completely and selectively blocked MAO-B activity and blocked DA metabolism in the caudate nucleus and frontal cortex. DA metabolism in the substantia nigra was not affected by MAO-B inhibition. Changes in DA metabolism were accompanied by changes in 5-hydroxytryptamine (5HT) turnover: 5-hydroxyindole acetic acid (5HIAA) levels increased in the caudate and decreased in the frontal cortex. Levels of 2-phenylethylamine (PE), a putative modulator of dopaminergic transmission, were increased by MAO-B inhibition in all three brain regions examined. It is concluded that in some regions of the primate brain, in contrast to the rat, MAO-B has an important role in DA metabolism.

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