The Relationship Between the Pressor Response to Involuntary Isometric Exercise and the Contractile Protein Profile of the Active Muscle in Man

Overview

Journal Eur J Appl Physiol Occup Physiol

Specialty Occupational Medicine

Date 1995 Jan 1

PMID 8789575

Citations 1

Authors

C A Carrington

M J White

S D Harridge

M Goodman

P Cummins

Affiliations

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Abstract

The present investigation examined the relationship between the pressor response during electrically evoked isometric ankle plantar flexion and the contractile protein profile of the active muscle in seven young men [mean (SD) age, 26 (6) years] and five older men [70 (4) years]. Muscle biopsy samples were taken from lateral gastrocnemius (LG) and soleus (SOL) of each subject. These were analysed for isomyosin composition using non-denaturing pyrophosphate polyacrylamide gel electrophoresis. The degree of association was examined between the cardiovascular changes and the fast isomyosin content of LG and SOL individually and in combination (SOL/LG). In the total subject group there was no association between the heart rate response or the change in systolic blood pressure (BP) and the fast isomyosin composition. However, the change in diastolic BP was significantly associated with the fast isomyosin composition of SOL/LG (delta diastolicBP = 0.31 + 0.045% FM SOL/LG, r = 0.65, P = 0.029). These findings suggest that the magnitude of the peripheral reflex mediated pressor response to isometric exercise and the fast isomyosin content of the active muscle are related.

Citing Articles

The time course and direction of lower limb vascular conductance changes during voluntary and electrically evoked isometric exercise of the contralateral calf muscle in man.

Fisher J, White M J Physiol. 2003; 546(Pt 1):315-23.

PMID: 12509499 PMC: 2342469. DOI: 10.1113/jphysiol.2002.031476.

References

White M, Carrington C . The pressor response to involuntary isometric exercise of young and elderly human muscle with reference to muscle contractile characteristics. Eur J Appl Physiol Occup Physiol. 1993; 66(4):338-42. DOI: 10.1007/BF00237779. View

Staron R, Pette D . Correlation between myofibrillar ATPase activity and myosin heavy chain composition in rabbit muscle fibers. Histochemistry. 1986; 86(1):19-23. DOI: 10.1007/BF00492341. View

Sadamoto T, Mutoh Y, Miyashita M . Cardiovascular reflexes during sustained handgrip exercise: role of muscle fibre composition, potassium and lactate. Eur J Appl Physiol Occup Physiol. 1992; 65(4):324-30. DOI: 10.1007/BF00868135. View

Davies C, Mecrow I, White M . Contractile properties of the human triceps surae with some observations on the effects of temperature and exercise. Eur J Appl Physiol Occup Physiol. 1982; 49(2):255-69. DOI: 10.1007/BF02334074. View

Bull R, Davies C, Lind A, White M . The human pressor response during and following voluntary and evoked isometric contraction with occluded local blood supply. J Physiol. 1989; 411:63-70. PMC: 1190511. DOI: 10.1113/jphysiol.1989.sp017560. View

DIETRICHSON P, Coakley J, Smith P, Griffiths R, Helliwell T, EDWARDS R . Conchotome and needle percutaneous biopsy of skeletal muscle. J Neurol Neurosurg Psychiatry. 1987; 50(11):1461-7. PMC: 1032558. DOI: 10.1136/jnnp.50.11.1461. View

Bobbert M, van Ingen Schenau G . Isokinetic plantar flexion: experimental results and model calculations. J Biomech. 1990; 23(2):105-19. DOI: 10.1016/0021-9290(90)90345-4. View

Petrofsky J, Lind A . The blood pressure response during isometric exercise in fast and slow twitch skeletal muscle in the cat. Eur J Appl Physiol Occup Physiol. 1980; 44(3):223-30. DOI: 10.1007/BF00421621. View

Frisk-Holmberg M, Essen B, Fredrikson M, Strom G, Wibell L . Muscle fibre composition in relation to blood pressure response to isometric exercise in normotensive and hypertensive subjects. Acta Med Scand. 1983; 213(1):21-6. DOI: 10.1111/j.0954-6820.1983.tb03683.x. View

10.

Klitgaard H, Zhou M, Schiaffino S, Betto R, Salviati G, Saltin B . Ageing alters the myosin heavy chain composition of single fibres from human skeletal muscle. Acta Physiol Scand. 1990; 140(1):55-62. DOI: 10.1111/j.1748-1716.1990.tb08975.x. View

11.

Leonard B, Mitchell J, Mizuno M, Rube N, Saltin B, Secher N . Partial neuromuscular blockade and cardiovascular responses to static exercise in man. J Physiol. 1985; 359:365-79. PMC: 1193380. DOI: 10.1113/jphysiol.1985.sp015590. View

12.

Billeter R, Heizmann C, Howald H, Jenny E . Analysis of myosin light and heavy chain types in single human skeletal muscle fibers. Eur J Biochem. 1981; 116(2):389-95. DOI: 10.1111/j.1432-1033.1981.tb05347.x. View

13.

Hoh J . Neural regulation of mammalian fast and slow muscle myosins: an electrophoretic analysis. Biochemistry. 1975; 14(4):742-7. DOI: 10.1021/bi00675a015. View

14.

Davies C, Starkie D . The pressor response to voluntary and electrically evoked isometric contractions in man. Eur J Appl Physiol Occup Physiol. 1985; 53(4):359-63. DOI: 10.1007/BF00422854. View

15.

Lexell J, TAYLOR C, Sjostrom M . What is the cause of the ageing atrophy? Total number, size and proportion of different fiber types studied in whole vastus lateralis muscle from 15- to 83-year-old men. J Neurol Sci. 1988; 84(2-3):275-94. DOI: 10.1016/0022-510x(88)90132-3. View

16.

Rice C, Cunningham D, Taylor A, Paterson D . Comparison of the histochemical and contractile properties of human triceps surae. Eur J Appl Physiol Occup Physiol. 1988; 58(1-2):165-70. DOI: 10.1007/BF00636621. View

17.

Taylor J, Hand G, Johnson D, Seals D . Sympathoadrenal-circulatory regulation during sustained isometric exercise in young and older men. Am J Physiol. 1991; 261(5 Pt 2):R1061-9. DOI: 10.1152/ajpregu.1991.261.5.R1061. View

18.

FitzSimons R, Hoh J . Isomyosins in human type 1 and type 2 skeletal muscle fibres. Biochem J. 1981; 193(1):229-33. PMC: 1162594. DOI: 10.1042/bj1930229. View