Comparison of Fluconazole and Amphotericin B for Treatment of Experimental Candida Albicans Endocarditis in Rabbits

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 1996 Jan 1

PMID 8787921

Citations 5

Authors

K Chemlal

V Joly

R Farinotti

N Seta

P Yeni

C Carbon

Affiliations

Soon will be listed here.

Abstract

Amphotericin B (AmB) and fluconazole, administered intraperitoneally for 7 days, were compared in a rabbit model for Candida albicans endocarditis. When given early, AmB was more effective than fluconazole for reducing CFU counts in vegetations (P < 0.01) and kidneys. Forty-eight hours after the last dose, AmB was still detected in all vegetations whereas fluconazole was detected in only one case.

Citing Articles

Activities and ultrastructural effects of antifungal combinations against simulated Candida endocardial vegetations.

Pai M, Samples M, Mercier R, Spilde M Antimicrob Agents Chemother. 2008; 52(7):2367-76.

PMID: 18426896 PMC: 2443905. DOI: 10.1128/AAC.01557-07.

Fungicidal synergism of fluconazole and cyclosporine in Candida albicans is not dependent on multidrug efflux transporters encoded by the CDR1, CDR2, CaMDR1, and FLU1 genes.

Marchetti O, Moreillon P, Entenza J, Vouillamoz J, Glauser M, Bille J Antimicrob Agents Chemother. 2003; 47(5):1565-70.

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Impact of the order of initiation of fluconazole and amphotericin B in sequential or combination therapy on killing of Candida albicans in vitro and in a rabbit model of endocarditis and pyelonephritis.

Louie A, Kaw P, Banerjee P, Liu W, Chen G, Miller M Antimicrob Agents Chemother. 2001; 45(2):485-94.

PMID: 11158745 PMC: 90317. DOI: 10.1128/AAC.45.2.485-494.2001.

Fluconazole plus cyclosporine: a fungicidal combination effective against experimental endocarditis due to Candida albicans.

Marchetti O, Entenza J, Sanglard D, Bille J, Glauser M, Moreillon P Antimicrob Agents Chemother. 2000; 44(11):2932-8.

PMID: 11036003 PMC: 101583. DOI: 10.1128/AAC.44.11.2932-2938.2000.

Efficacies of high-dose fluconazole plus amphotericin B and high-dose fluconazole plus 5-fluorocytosine versus amphotericin B, fluconazole, and 5-fluorocytosine monotherapies in treatment of experimental endocarditis, endophthalmitis, and....

Louie A, Liu W, Miller D, Sucke A, Liu Q, Drusano G Antimicrob Agents Chemother. 1999; 43(12):2831-40.

PMID: 10582868 PMC: 89573. DOI: 10.1128/AAC.43.12.2831.

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