Keenamide A, a Bioactive Cyclic Peptide from the Marine Mollusk Pleurobranchus Forskalii

Overview

Journal J Nat Prod

Date 1996 Jun 1

PMID 8786369

Citations 21

Authors

K J Wesson

M T Hamann

Affiliations

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Abstract

Keenamide A (1), a new cytotoxic cyclic hexapeptide, was isolated from the notaspidean mollusk Pleurobranchus forskalii. Its structure was determined by NMR spectral data interpretation and chiral amino acid analysis. Keenamide A (1) exhibited significant activity against the P-388, A-549, MEL-20, and HT-29 tumor cell lines, but was inactive when evaluated against the D6 and W2 Plasmodium falciparum malarial clones.

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