Neutralizing Antibodies to Different Proteins of African Swine Fever Virus Inhibit Both Virus Attachment and Internalization

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 1996 Aug 1

PMID 8764090

Citations 76

Authors

P Gomez-Puertas

F Rodriguez

J M Oviedo

F Ramiro-Ibanez

C Alonso

J M Escribano

Affiliations

Soon will be listed here.

Abstract

African swine fever virus induces in convalescent pigs antibodies that neutralized the virus before and after binding to susceptible cells, inhibiting both virus attachment and internalization. A further analysis of the neutralization mechanisms mediated by the different viral proteins showed that antibodies to proteins p72 and p54 are involved in the inhibition of a first step of the replication cycle related to virus attachment, while antibodies to protein p30 are implicated in the inhibition of virus internalization.

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