Myocardial Imaging with Thallium-201: an Experimental Model for Analysis of the True Myocardial and Background Image Components

Overview

Journal J Nucl Med

Specialty Nuclear Medicine

Date 1977 Aug 1

PMID 874163

Citations 13

Authors

K A Narahara

G W Hamilton

D L Williams

K L Gould

Affiliations

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Abstract

The true myocardial and background components of a resting thallium-201 myocardial image were determined in an experimental dog model. True background was determined by imaging after the heart had been removed and replaced with a water-filled balloon of equal size and shape. In all studies, the background estimated from the region surrounding the heart exceeded true background activity. Furthermore, the relationship between true myocardial background and that estimated from the pericardiac region was inconsistent. Background estimates based on the activity surrounding the heart were not accurate predictors of true background activity.

Citing Articles

Quantitative relationship of stress Tc-99m sestamibi lung uptake with resting Tl-201 lung uptake and with indices of left ventricular dysfunction and coronary artery disease.

Patel G, Hauser T, Parker J, Pinto D, Sanders G, Aepfelbacher F J Nucl Cardiol. 2004; 11(4):408-13.

PMID: 15295409 DOI: 10.1016/j.nuclcard.2004.03.032.

Increased resting Tl-201 lung-to-heart ratio is associated with invasively determined measures of left ventricular dysfunction, extent of coronary artery disease, and resting myocardial perfusion abnormalities.

Sanders G, Pinto D, Parker J, Koutkia P, Aepfelbacher F, Danias P J Nucl Cardiol. 2003; 10(2):140-7.

PMID: 12673178 DOI: 10.1067/mnc.2003.399.

Effect of stenosed and occluded coronary arteries on immediate and late myocardial uptake of thallium-201.

Clitsakis D, Layton C, Battersby W, Johns M, STOCKLEY A Br Heart J. 1981; 46(2):186-9.

PMID: 7272129 PMC: 482626. DOI: 10.1136/hrt.46.2.186.

Thallium-201 myocardial scintigraphy: fractional uptake by the myocardium at rest and during exercise in patients with coronary artery disease and hypertrophic cardiomyopathy.

Kambara H, Ishii Y, Kadota K, Yonekura Y, Torizuka K, Kawai C Eur J Nucl Med. 1980; 5(6):493-8.

PMID: 7193139 DOI: 10.1007/BF00252038.

Detection of lesions in thallium-201 myocardial perfusion scintigraphy.

Vos P, Vossepoel A, Hermans J, Pauwels E Eur J Nucl Med. 1982; 7(4):174-80.

PMID: 7075619 DOI: 10.1007/BF00443927.