The Effect of Heart Rate and Contractility on the Measurement of Left Ventricular Mass by 201Tl SPECT

Overview

Journal Eur J Nucl Med

Specialty Nuclear Medicine

Date 1987 Jan 1

PMID 3501983

Citations 1

Authors

J Machac

R Vaquer

H Levin

S F Horowitz

Affiliations

Soon will be listed here.

Abstract

Left ventricular myocardial mass can be measured by 201Tl SPECT, but the effects of changes in heart rate and contractility have not been determined. We constructed a dynamic computer model simulating the contracting left ventricle. Thirty two summed static views at each of 3 heart rates and 3 ejection fractions were manufactured to simulate a 180 degrees acquisition. Each image set underwent tomographic reconstruction. Left ventricular mass was measured at a fixed percent threshold in each slice. The results show that left ventricular mass varied little with heart rate (4%) and only slightly more (8%) with ejection fraction. Thus, in the normal clinical setting, left ventricular mass measurements by SPECT are minimally affected by the dynamic state of the heart.

Citing Articles

A historical perspective on measurement of ventricular function with scintigraphic techniques: Part II--Ventricular function with gated techniques for blood pool and perfusion imaging.

Williams K J Nucl Cardiol. 2005; 12(2):208-15.

PMID: 15812376 DOI: 10.1016/j.nuclcard.2005.01.004.

References

Colan S, Borow K, GAMBLE W, Sanders S . Effects of enhanced afterload (methoxamine) and contractile state (dobutamine) on the left ventricular late-systolic wall stress-dimension relation. Am J Cardiol. 1983; 52(10):1304-9. DOI: 10.1016/0002-9149(83)90593-3. View

Gould K, Lipscomb K, Hamilton G, Kennedy J . Relation of left ventricular shape, function and wall stress in man. Am J Cardiol. 1974; 34(6):627-34. DOI: 10.1016/0002-9149(74)90149-0. View

Suzuki Y, Kadota K, Nohara R, Tamaki S, Kambara H, Yoshida A . Recognition of regional hypertrophy in hypertrophic cardiomyopathy using thallium-201 emission-computed tomography: comparison with two-dimensional echocardiography. Am J Cardiol. 1984; 53(8):1095-102. DOI: 10.1016/0002-9149(84)90644-1. View

Links J, Becker L, Shindledecker J, Guzman P, Burow R, Nickoloff E . Measurement of absolute left ventricular volume from gated blood pool studies. Circulation. 1982; 65(1):82-91. DOI: 10.1161/01.cir.65.1.82. View

Machac J, Levin H, Balk E, Horowitz S . Computer modeling of planar myocardial perfusion imaging: effect of heart rate and ejection fraction on wall thickness and chamber size. J Nucl Med. 1986; 27(5):653-9. View

HOLMAN B, Moore S, Shulkin P, Kirsch C, English R, Hill T . Quantitation of perfused myocardial mass using Tl-201 and emission computed tomography. Invest Radiol. 1983; 18(4):322-6. DOI: 10.1097/00004424-198307000-00006. View

Lange K, Carson R . EM reconstruction algorithms for emission and transmission tomography. J Comput Assist Tomogr. 1984; 8(2):306-16. View

Vos P, Vossepoel A, Hermans J, Pauwels E . Detection of lesions in thallium-201 myocardial perfusion scintigraphy. Eur J Nucl Med. 1982; 7(4):174-80. DOI: 10.1007/BF00443927. View

Wolfe C, Corbett J, Lewis S, Buja L, Willerson J . Determination of left ventricular mass by single-photon emission computed tomography with thallium-201. Am J Cardiol. 1984; 53(9):1365-8. DOI: 10.1016/0002-9149(84)90095-x. View

10.

Edwards W, Tajik A, Seward J . Standardized nomenclature and anatomic basis for regional tomographic analysis of the heart. Mayo Clin Proc. 1981; 56(8):479-97. View

11.

MacMahon S, Wilcken D, Macdonald G . The effect of weight reduction on left ventricular mass. A randomized controlled trial in young, overweight hypertensive patients. N Engl J Med. 1986; 314(6):334-9. DOI: 10.1056/NEJM198602063140602. View

12.

Braunwald E, Kloner R . The stunned myocardium: prolonged, postischemic ventricular dysfunction. Circulation. 1982; 66(6):1146-9. DOI: 10.1161/01.cir.66.6.1146. View

13.

Wainwright R, Cueni T, Sowton E, Hilson A, Maisey M . Cold pressor test in detection of coronary heart-disease and cardiomyopathy using technetium-99m gated blood-pool imaging. Lancet. 1979; 2(8138):320-3. DOI: 10.1016/s0140-6736(79)90341-6. View

14.

Hugenholtz P, Kaplan E, HULL E . Determination of left ventricular wall thickness by angiocardiography. Am Heart J. 1969; 78(4):513-22. DOI: 10.1016/0002-8703(69)90486-4. View

15.

Horowitz S, Machac J, Levin H, Matza D . Effect of variable left ventricular vertical orientation on planar myocardial perfusion images. J Nucl Med. 1986; 27(5):694-700. View

16.

Hoffman E, Huang S, Phelps M . Quantitation in positron emission computed tomography: 1. Effect of object size. J Comput Assist Tomogr. 1979; 3(3):299-308. DOI: 10.1097/00004728-197906000-00001. View

17.

TAUXE W, Soussaline F, Todd-Pokropek A, Cao A, Collard P, Richard S . Determination of organ volume by single-photon emission tomography. J Nucl Med. 1982; 23(11):984-7. View

18.

Herman M, Heinle R, Klein M, Gorlin R . Localized disorders in myocardial contraction. Asynergy and its role in congestive heart failure. N Engl J Med. 1967; 277(5):222-32. DOI: 10.1056/NEJM196708032770502. View

19.

Clayton P, Jeppson G, Klausner S . Should a fixed external reference system be used to analyze left ventricular wall motion?. Circulation. 1982; 65(7):1518-21. DOI: 10.1161/01.cir.65.7.1518. View

20.

Narahara K, Hamilton G, Williams D, Gould K . Myocardial imaging with thallium-201: an experimental model for analysis of the true myocardial and background image components. J Nucl Med. 1977; 18(8):781-6. View