Mammary Tumors Induced by Polyomavirus

Overview

Journal Breast Cancer Res Treat

Specialty Oncology

Date 1996 Jan 1

PMID 8738605

Citations 7

Authors

M M Fluck

S Z Haslam

Affiliations

Soon will be listed here.

Abstract

The first known member of the Polyomavirus family, murine Polyomavirus (MPyV), was discovered because of its oncogenic properties. The genetic simplicity of MPyV (shared with all members of the Py family), the wide spectrum of tumors induced by MPyV, and the convenient properties of its natural host, the mouse, make it a particularly interesting model system to study oncogenesis. This paper briefly reviews the virus infectious cycle and our current understanding of the viral proteins that are involved in oncogenesis, and focuses on recent studies on oncogenesis of the mammary gland. Mammary gland ductal adenocarcinomas develop at high frequency and with short latency in infected immunoincompetent adult female or normal neonatal mice or in transgenic mice expressing the viral oncogene, middle T. These tumors provide excellent model systems for the study of human breast cancer.

Citing Articles

Polyomaviruses and the risk of breast cancer: a systematic review and meta-analysis.

Mousavi T, Shokoohy F, Moosazadeh M Infect Agent Cancer. 2025; 20(1):14.

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A Transformation-Defective Polyomavirus Middle T Antigen with a Novel Defect in PI3 Kinase Signaling.

Denis D, Rouleau C, Schaffhausen B J Virol. 2016; 91(2).

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Transformation by Polyomavirus Middle T Antigen Involves a Unique Bimodal Interaction with the Hippo Effector YAP.

Rouleau C, Pores Fernando A, Hwang J, Faure N, Jiang T, White E J Virol. 2016; 90(16):7032-7045.

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Guidelines for the welfare and use of animals in cancer research.

Workman P, Aboagye E, Balkwill F, Balmain A, Bruder G, Chaplin D Br J Cancer. 2010; 102(11):1555-77.

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Lessons in signaling and tumorigenesis from polyomavirus middle T antigen.

Fluck M, Schaffhausen B Microbiol Mol Biol Rev. 2009; 73(3):542-63, Table of Contents.

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