Animal Models of Breast Cancer: Their Diversity and Role in Biomedical Research

Overview

Journal Breast Cancer Res Treat

Specialty Oncology

Date 1996 Jan 1

PMID 8738601

Citations 17

Authors

R Clarke

Affiliations

Soon will be listed here.

Abstract

Animal models of breast cancer have been widely used to study various aspects of breast cancer biology, and are remarkably diverse, encompassing chemically and virally induced tumors, human tumor xenografts, and transgenic mouse models. Several novel models have become available during the past few years, including tumors induced by polyomavirus and adenovirus, and a series of human cell line variants. The several following articles describe, in some detail, the characteristics of these models and their relevance to the human disease. Descriptions of each of the major models, e.g., 7,12-dimethylbenz(a)anthracene-induced, MMTV-associated, and human breast cancer cell line xenografts, also are included. The limitations and advantages of several of these models, and some issues relating to the choice of models, are briefly discussed in this overview.

Citing Articles

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Large Animal Models of Breast Cancer.

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The Detection and Morphological Analysis of Circulating Tumor and Host Cells in Breast Cancer Xenograft Models.

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