The N Gene of Tobacco Confers Resistance to Tobacco Mosaic Virus in Transgenic Tomato

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1996 Aug 6

PMID 8710948

Citations 70

Authors

S Whitham

S McCormick

B Baker

Affiliations

Soon will be listed here.

Abstract

It has been proposed that cloned plant disease resistance genes could be transferred from resistant to susceptible plant species to control important crop plant diseases. The recently cloned N gene of tobacco confers resistance to the viral pathogen, tobacco mosaic virus. We generated transgenic tomato plants bearing the N gene and demonstrate that N confers a hypersensitive response and effectively localizes tobacco mosaic virus to sites of inoculation in transgenic tomato, as it does in tobacco. The ability to reconstruct the N-mediated resistance response to tobacco mosaic virus in tomato demonstrates the utility of using isolated resistance genes to protect crop plants from diseases, and it demonstrates that all the components necessary for N-mediated resistance are conserved in tomato.

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