Characterization of Tumor Cell Lines Derived from Murine Gammaherpesvirus-68-infected Mice

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 1996 Sep 1

PMID 8709292

Citations 61

Authors

E J Usherwood

J P Stewart

A A Nash

Affiliations

Soon will be listed here.

Abstract

Cell lines were derived from mice with murine gammaherpesvirus-68 (MHV-68)-associated lymphoproliferative disease. Four were of an ambiguous phenotype and were MHV-68 negative. One, S11, was a B lymphocyte that contained MHV-68 genomes in both linear and episomal forms and released virus. The line was clonable and grew into tumors in nude mice. This is the first naturally occurring MHV-68-positive B-cell line to be generated, and it will be an invaluable tool for the study of MHV-68 latency.

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