Alpha 2.0
Login Register
» Articles » PMID: 8708650

Treatment of Chronic Inflammatory Demyelinating Polyneuropathy with Cyclosporin-A

Overview
Journal J Neurol Neurosurg Psychiatry
Publisher BMJ Publishing Group
Specialties Neurology
Neurosurgery
Psychiatry
Date 1996 Feb 1
PMID 8708650
Citations 14
Authors
W Mahattanakul
T O Crawford
J W Griffin
J M Goldstein
D R Cornblath
Affiliations
Soon will be listed here.
Abstract

Chronic inflammatory demyelinating polyneuropathy (CIDP) is an immune mediated polyneuropathy for which there are effective therapies. However, not all patients improve with these treatments. Eight patients with CIDP, two with IgG monoclonal gammopathies, were treated with cyclosporin-A (3 to 5 mg/kg/day). In three, this treatment was successful. It was unsuccessful in four patients who were resistant to other treatments and in one who had initially received cyclosporin-A. There were no serious side effects. In selected patients with CIDP, cyclosporin-A is a potentially useful treatment.

Citing Articles

Immune-mediated neuropathies.

Kieseier B, Mathey E, Sommer C, Hartung H Nat Rev Dis Primers. 2018; 4(1):31.

PMID: 30310069 DOI: 10.1038/s41572-018-0027-2.

Immunomodulatory treatment other than corticosteroids, immunoglobulin and plasma exchange for chronic inflammatory demyelinating polyradiculoneuropathy.

Mahdi-Rogers M, Brassington R, Gunn A, van Doorn P, Hughes R Cochrane Database Syst Rev. 2017; 5:CD003280.

PMID: 28481421 PMC: 6481566. DOI: 10.1002/14651858.CD003280.pub5.

Chronic inflammatory demyelinating polyradiculoneuropathy: from bench to bedside.

Peltier A, D Donofrio P Semin Neurol. 2012; 32(3):187-95.

PMID: 23117943 PMC: 4845954. DOI: 10.1055/s-0032-1329194.

Standard and escalating treatment of chronic inflammatory demyelinating polyradiculoneuropathy.

Yoon M, Chan A, Gold R Ther Adv Neurol Disord. 2011; 4(3):193-200.

PMID: 21694819 PMC: 3105635. DOI: 10.1177/1756285611405564.

Potential of immunosuppressive agents in cerebral ischaemia.

Gupta Y, Chauhan A Indian J Med Res. 2011; 133:15-26.

PMID: 21321416 PMC: 3100142.

References
1.
Gross M, Thomas P . The treatment of chronic relapsing and chronic progressive idiopathic inflammatory polyneuropathy by plasma exchange. J Neurol Sci. 1981; 52(1):69-78. DOI: 10.1016/0022-510x(81)90135-0. View
2.
Kolkin S, Nahman Jr N, Mendell J . Chronic nephrotoxicity complicating cyclosporine treatment of chronic inflammatory demyelinating polyradiculoneuropathy. Neurology. 1987; 37(1):147-9. DOI: 10.1212/wnl.37.1.147. View
3.
Jongen P, Joosten E, Berden J, Gabreels-Festen A . Cyclosporine therapy in chronic inflammatory demyelinating polyradiculoneuropathy--a preliminary report of clinical results in two patients. Transplant Proc. 1988; 20(3 Suppl 4):329-32. View
4.
Tindall R . Immunointervention with cyclosporin A in autoimmune neurological disorders. J Autoimmun. 1992; 5 Suppl A:301-13. DOI: 10.1016/0896-8411(92)90048-u. View
5.
Hefter H, Sprenger K, Arendt G, Hafner D . Treatment of chronic relapsing inflammatory demyelinating polyneuropathy by cyclosporin A and plasma exchange. A case report. J Neurol. 1990; 237(5):320-3. DOI: 10.1007/BF00314752. View