Cyclosporin A in the Treatment of Chronic Demyelinating Polyradiculoneuropathy

Overview

Journal J Neurol Neurosurg Psychiatry

Publisher BMJ Publishing Group

Specialties Neurology
Neurosurgery
Psychiatry

Date 1990 Apr 1

PMID 2341846

Citations 17

Authors

S J Hodgkinson

J D Pollard

J G McLeod

Affiliations

Soon will be listed here.

Abstract

Eight patients with chronic inflammatory demyelinating polyneuropathy, five of whom had an associated paraproteinaemia, were treated with cyclosporin in a pilot, uncontrolled study for periods up to three and a half years after failing to respond adequately to corticosteroid and azathioprine therapy and plasmapheresis. Three patients had an excellent response, two with complete remission. In other cases it was possible to reduce the corticosteroid therapy and frequency of plasmapheresis. There were no serious complications of the treatment.

Citing Articles

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Tacrolimus treatment for relapsing-remitting chronic inflammatory demyelinating polyradiculoneuropathy: Two case reports.

Zhu W, Da Y, Chen H, Xu M, Lu Y, Di L World J Clin Cases. 2022; 10(5):1709-1715.

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Immunomodulatory treatment other than corticosteroids, immunoglobulin and plasma exchange for chronic inflammatory demyelinating polyradiculoneuropathy.

Mahdi-Rogers M, Brassington R, Gunn A, van Doorn P, Hughes R Cochrane Database Syst Rev. 2017; 5:CD003280.

PMID: 28481421 PMC: 6481566. DOI: 10.1002/14651858.CD003280.pub5.

Immunotherapy for IgM anti-myelin-associated glycoprotein paraprotein-associated peripheral neuropathies.

Lunn M, Nobile-Orazio E Cochrane Database Syst Rev. 2016; 10:CD002827.

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Multifocal motor neuropathy, multifocal acquired demyelinating sensory and motor neuropathy, and other chronic acquired demyelinating polyneuropathy variants.

Dimachkie M, Barohn R, Katz J Neurol Clin. 2013; 31(2):533-55.

PMID: 23642723 PMC: 4098937. DOI: 10.1016/j.ncl.2013.01.001.

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