Pathogenic and Protective Correlates of T Cell Proliferation in AIDS. HNRC Group. HIV Neurobehavioral Research Center

Overview

Journal J Clin Invest

Specialty General Medicine

Date 1996 Aug 1

PMID 8698865

Citations 10

Authors

R D Schrier

C A Wiley

C Spina

J A McCutchan

I Grant

Affiliations

Soon will be listed here.

Abstract

To investigate the association of antigen specific CD4 T cell activation with HIV disease progression and AIDS-related central nervous system damage, T cell proliferation responses to HIV, CMV, and HSV were evaluated in infected individuals. CD4 T cell loss and neurocognitive impairment were assessed at 6-mo intervals. Individuals with known times of seroconversion who responded to more HIV peptides were at greater risk of progressing to < 200 CD4 T cells (P = 0.04) and dying (P = 0.03) than those with responses to fewer peptides. A positive correlation (0.52) was seen between the breadth of the HIV proliferation response and HIV plasma RNA levels. Higher proliferation responses to CMV and HSV were also associated with more rapid CD4 loss (P = 0.05). HLA phenotyped individuals (n = 150) with two HLA-DR alleles associated with response to more HIV peptides and CMV (DR-2,5,w6,10) were less likely to develop neurocognitive (P = 0.002) and neurologic impairment (P = 0.04), but were not protected from CD4 loss and death. Thus, the ability to generate a greater T cell proliferation response to HIV and opportunistic herpes viruses may lead to resistance to central nervous system damage, but also risk of more rapid HIV disease progression.

Citing Articles

Neurocognitive Impairment and Associated Genetic Aspects in HIV Infection.

Gomez D, Power C, Fujiwara E Curr Top Behav Neurosci. 2018; 50:41-76.

PMID: 30523615 DOI: 10.1007/7854_2018_69.

Cerebrospinal fluid (CSF) CD8+ T-cells that express interferon-gamma contribute to HIV associated neurocognitive disorders (HAND).

Schrier R, Hong S, Crescini M, Ellis R, Perez-Santiago J, Spina C PLoS One. 2015; 10(2):e0116526.

PMID: 25719800 PMC: 4342256. DOI: 10.1371/journal.pone.0116526.

The influence of HLA on HIV-associated neurocognitive impairment in Anhui, China.

Schrier R, Gupta S, Riggs P, Cysique L, Letendre S, Jin H PLoS One. 2012; 7(5):e32303.

PMID: 22693541 PMC: 3365058. DOI: 10.1371/journal.pone.0032303.

Immune correlates of CD4 decline in HIV-infected patients experiencing virologic failure before undergoing treatment interruption.

Huang K, Loutfy M, Tsoukas C, Bernard N BMC Infect Dis. 2008; 8:59.

PMID: 18454861 PMC: 2405786. DOI: 10.1186/1471-2334-8-59.

Preferential infection shortens the life span of human immunodeficiency virus-specific CD4+ T cells in vivo.

Brenchley J, Ruff L, Casazza J, Koup R, Price D, Douek D J Virol. 2006; 80(14):6801-9.

PMID: 16809286 PMC: 1489023. DOI: 10.1128/JVI.00070-06.

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