Incidence of Chromosome 21 Disomy in Human Spermatozoa As Determined by Fluorescent In-situ Hybridization

Overview

Journal Hum Reprod

Publisher Oxford University Press

Specialty Reproductive Medicine

Date 1996 Apr 1

PMID 8671315

Citations 14

Authors

J Blanco

J Egozcue

F Vidal

Affiliations

Soon will be listed here.

Abstract

We have evaluated the incidence of chromosome 21 disomy in decondensed sperm heads from nine normal men using a locus-specific DNA probe for chromosome 21, and a centromeric probe for chromosome 6 as a control. The results show that the incidence of chromosome 21 disomy (0.38%) is significantly higher than disomy for chromosome 6(0.14%). No differences were found among the individuals analysed.

Citing Articles

Chromosome heteromorphisms: do they entail a reproductive risk for male carriers?.

Anton E, Garcia-Guixe E, Ramos-Muntada M, Godo A, Sandalinas M, Blanco J Asian J Androl. 2020; 22(5):544-546.

PMID: 31929195 PMC: 7523617. DOI: 10.4103/aja.aja_130_19.

The use of fluorescence in situ hybridization analysis on sperm: indications to perform and assisted reproduction technology outcomes.

Sarrate Z, Blanco J, Marina-Rugero F, Moreno-Garcia J, Ruiz-Jorro M, Lafuente-Varea R J Assist Reprod Genet. 2019; 36(10):1975-1987.

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Preliminary analysis of numerical chromosome abnormalities in reciprocal and Robertsonian translocation preimplantation genetic diagnosis cases with 24-chromosomal analysis with an aCGH/SNP microarray.

Xie Y, Xu Y, Wang J, Miao B, Zeng Y, Ding C J Assist Reprod Genet. 2017; 35(1):177-186.

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Meiotic abnormalities in metaphase I human spermatocytes from infertile males: frequencies, chromosomes involved, and the relationships with polymorphic karyotype and seminal parameters.

Sarrate Z, Vidal F, Blanco J Asian J Androl. 2014; 16(6):838-44.

PMID: 25080930 PMC: 4236326. DOI: 10.4103/1008-682X.135126.

Sequential FISH allows the determination of the segregation outcome and the presence of numerical anomalies in spermatozoa from a t(1;8;2)(q42;p21;p15) carrier.

Godo A, Blanco J, Vidal F, Parriego M, Boada M, Anton E J Assist Reprod Genet. 2013; 30(9):1115-23.

PMID: 23975190 PMC: 3800523. DOI: 10.1007/s10815-013-0063-5.