Qualitative Analysis of Biochemical Reaction Systems

Overview

Journal Comput Biol Med

Publisher Elsevier

Specialties Biology
General Medicine
Medical Informatics

Date 1996 Jan 1

PMID 8654057

Citations 24

Authors

V N Reddy

M N Liebman

M L Mavrovouniotis

Affiliations

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Abstract

The qualitative analysis of biochemical reaction systems is presented. A discrete event systems approach is used to represent and analyze bioreaction pathways. The approach is based on Petri nets, which are particularly suited to modeling stoichiometric transformations, i.e. the inter-conversion of metabolites in fixed proportions. The properties and methods for the analysis of Petri nets, along with their interpretation for biochemical systems, are presented. As an example, the combined glycolytic and pentose phosphate pathway of the erythrocyte cell is presented to illustrate the concepts of the methodology.

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