Origin of Genetic Code: A Needle in the Haystack of TRNA Sequences

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1996 May 14

PMID 8643435

Citations 12

Authors

P Schimmel

Affiliations

Soon will be listed here.

Citing Articles

The Role of tRNA-Derived Small RNAs (tsRNAs) in Regulating Cell Death of Cardiovascular Diseases.

Guo J, Chen X, Ren J, Wang Y, Wang K, Yang S Biology (Basel). 2025; 14(2).

PMID: 40001986 PMC: 11853139. DOI: 10.3390/biology14020218.

Origin of the Genetic Code Is Found at the Transition between a Thioester World of Peptides and the Phosphoester World of Polynucleotides.

Hartman H, Smith T Life (Basel). 2019; 9(3).

PMID: 31443422 PMC: 6789786. DOI: 10.3390/life9030069.

Interdependence, Reflexivity, Fidelity, Impedance Matching, and the Evolution of Genetic Coding.

Carter Jr C, Wills P Mol Biol Evol. 2017; 35(2):269-286.

PMID: 29077934 PMC: 5850816. DOI: 10.1093/molbev/msx265.

Coding of Class I and II Aminoacyl-tRNA Synthetases.

Carter Jr C Adv Exp Med Biol. 2017; 966:103-148.

PMID: 28828732 PMC: 5927602. DOI: 10.1007/5584_2017_93.

Beyond the Frozen Accident: Glycine Assignment in the Genetic Code.

Tamura K J Mol Evol. 2015; 81(3-4):69-71.

PMID: 26289730 DOI: 10.1007/s00239-015-9694-8.

References

Rich A, RajBhandary U . Transfer RNA: molecular structure, sequence, and properties. Annu Rev Biochem. 1976; 45:805-60. DOI: 10.1146/annurev.bi.45.070176.004105. View

Weiner A, Maizels N . tRNA-like structures tag the 3' ends of genomic RNA molecules for replication: implications for the origin of protein synthesis. Proc Natl Acad Sci U S A. 1987; 84(21):7383-7. PMC: 299300. DOI: 10.1073/pnas.84.21.7383. View

DE DUVE C . Transfer RNAs: the second genetic code. Nature. 1988; 333(6169):117-8. DOI: 10.1038/333117a0. View

Eigen M, Lindemann B, Tietze M, Dress A, Von Haeseler A . How old is the genetic code? Statistical geometry of tRNA provides an answer. Science. 1989; 244(4905):673-9. DOI: 10.1126/science.2497522. View

Moller W, Janssen G . Transfer RNAs for primordial amino acids contain remnants of a primitive code at position 3 to 5. Biochimie. 1990; 72(5):361-8. DOI: 10.1016/0300-9084(90)90033-d. View

Moller W, Janssen G . Statistical evidence for remnants of the primordial code in the acceptor stem of prokaryotic transfer RNA. J Mol Evol. 1992; 34(6):471-7. DOI: 10.1007/BF00160461. View

Hou Y, Sterner T, Bhalla R . Evidence for a conserved relationship between an acceptor stem and a tRNA for aminoacylation. RNA. 1995; 1(7):707-13. PMC: 1369312. View

Schimmel P, Giege R, Moras D, Yokoyama S . An operational RNA code for amino acids and possible relationship to genetic code. Proc Natl Acad Sci U S A. 1993; 90(19):8763-8. PMC: 47440. DOI: 10.1073/pnas.90.19.8763. View

Wang H, Lambowitz A . The Mauriceville plasmid reverse transcriptase can initiate cDNA synthesis de novo and may be related to reverse transcriptase and DNA polymerase progenitor. Cell. 1993; 75(6):1071-81. DOI: 10.1016/0092-8674(93)90317-j. View

10.

Frugier M, Florentz C, Giege R . Efficient aminoacylation of resected RNA helices by class II aspartyl-tRNA synthetase dependent on a single nucleotide. EMBO J. 1994; 13(9):2218-26. PMC: 395077. DOI: 10.1002/j.1460-2075.1994.tb06499.x. View

11.

Maizels N, Weiner A . Phylogeny from function: evidence from the molecular fossil record that tRNA originated in replication, not translation. Proc Natl Acad Sci U S A. 1994; 91(15):6729-34. PMC: 44276. DOI: 10.1073/pnas.91.15.6729. View

12.

Schimmel P, Ribas de Pouplana L . Transfer RNA: from minihelix to genetic code. Cell. 1995; 81(7):983-6. DOI: 10.1016/s0092-8674(05)80002-9. View

13.

Dick T, Schamel W . Molecular evolution of transfer RNA from two precursor hairpins: implications for the origin of protein synthesis. J Mol Evol. 1995; 41(1):1-9. DOI: 10.1007/BF00174035. View

14.

Steinberg S, Misch A, Sprinzl M . Compilation of tRNA sequences and sequences of tRNA genes. Nucleic Acids Res. 1993; 21(13):3011-5. PMC: 309727. DOI: 10.1093/nar/21.13.3011. View