T Cell Receptor-dependent Cell Death of T Cell Hybridomas Mediated by the CD30 Cytoplasmic Domain in Association with Tumor Necrosis Factor Receptor-associated Factors

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1996 Feb 1

PMID 8627180

Citations 35

Authors

S Y Lee

C G Park

Y Choi

Affiliations

Soon will be listed here.

Abstract

CD30 is a member of the tumor necrosis factor superfamily and a surface marker for Hodgkin's disease. Normal activated T cells and several virally transformed T or B cell lines also show CD30 expression. The interaction of CD30 with its ligand induces cell death or proliferation, depending on the cell type. In this report we characterize the signals mediated by the intracellular domain of CD30 and show that, in combination with signal(s) transduced by the T cell receptor, the multimerization of CD30 cytoplasmic domain induces Fas(CD95)-independent cell death in T cell hybridomas. Deletion analysis shows that the COOH-terminal 66 amino acids of CD30 are required to induce cell death. Using the yeast two-hybrid system, we have identified that the same region of CD30 interacts with tumor necrosis factor receptor-associated factor (TRAF)1 and TRAF2. These results indicate that TRAF1 and/or TRAF2 play an important role in cell death in addition to their previously identified roles in cell proliferation.

Citing Articles

A novel anti-membrane CD30 single-chain variable fragment discovered from the human phage library: A potential targeted immunotherapy.

Chanpong T, Seesuay W, Chiangjong W, Jiramornimit P, Preedagasamzin S, Atjanasuppat K PLoS One. 2023; 18(4):e0284708.

PMID: 37079526 PMC: 10118152. DOI: 10.1371/journal.pone.0284708.

Fourth Report on Chicken Genes and Chromosomes 2022.

Smith J, Alfieri J, Anthony N, Arensburger P, Athrey G, Balacco J Cytogenet Genome Res. 2023; 162(8-9):405-528.

PMID: 36716736 PMC: 11835228. DOI: 10.1159/000529376.

TNF Receptor Associated Factor 2 (TRAF2) Signaling in Cancer.

Siegmund D, Wagner J, Wajant H Cancers (Basel). 2022; 14(16).

PMID: 36011046 PMC: 9406534. DOI: 10.3390/cancers14164055.

Anaplastic large cell lymphoma: pathology, genetics, and clinical aspects.

Tsuyama N, Sakamoto K, Sakata S, Dobashi A, Takeuchi K J Clin Exp Hematop. 2017; 57(3):120-142.

PMID: 29279550 PMC: 6144189. DOI: 10.3960/jslrt.17023.

Progressive Multifocal Leukoencephalopathy and Monoclonal Antibodies: A Review.

Bohra C, Sokol L, Dalia S Cancer Control. 2017; 24(4):1073274817729901.

PMID: 28975841 PMC: 5937251. DOI: 10.1177/1073274817729901.

References

Schwab U, STEIN H, Gerdes J, Lemke H, Kirchner H, Schaadt M . Production of a monoclonal antibody specific for Hodgkin and Sternberg-Reed cells of Hodgkin's disease and a subset of normal lymphoid cells. Nature. 1982; 299(5878):65-7. DOI: 10.1038/299065a0. View

Stanger B, Leder P, Lee T, Kim E, Seed B . RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death. Cell. 1995; 81(4):513-23. DOI: 10.1016/0092-8674(95)90072-1. View

Littman D, Thomas Y, Maddon P, Chess L, Axel R . The isolation and sequence of the gene encoding T8: a molecule defining functional classes of T lymphocytes. Cell. 1985; 40(2):237-46. DOI: 10.1016/0092-8674(85)90138-2. View

Mackenzie D, ARENDT A, Hargrave P, McDowell J, Molday R . Localization of binding sites for carboxyl terminal specific anti-rhodopsin monoclonal antibodies using synthetic peptides. Biochemistry. 1984; 23(26):6544-9. DOI: 10.1021/bi00321a041. View

STEIN H, Mason D, Gerdes J, OConnor N, Wainscoat J, Pallesen G . The expression of the Hodgkin's disease associated antigen Ki-1 in reactive and neoplastic lymphoid tissue: evidence that Reed-Sternberg cells and histiocytic malignancies are derived from activated lymphoid cells. Blood. 1985; 66(4):848-58. View

Smith D, Johnson K . Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. Gene. 1988; 67(1):31-40. DOI: 10.1016/0378-1119(88)90005-4. View

Miller A, Rosman G . Improved retroviral vectors for gene transfer and expression. Biotechniques. 1989; 7(9):980-2, 984-6, 989-90. PMC: 1360503. View

Kolodziej P, Young R . Epitope tagging and protein surveillance. Methods Enzymol. 1991; 194:508-19. DOI: 10.1016/0076-6879(91)94038-e. View

Brannan C, Itoh N, Yonehara S, Copeland N, Jenkins N, Nagata S . The cDNA structure, expression, and chromosomal assignment of the mouse Fas antigen. J Immunol. 1992; 148(4):1274-9. View

10.

Durkop H, Latza U, Hummel M, Eitelbach F, Seed B, STEIN H . Molecular cloning and expression of a new member of the nerve growth factor receptor family that is characteristic for Hodgkin's disease. Cell. 1992; 68(3):421-7. DOI: 10.1016/0092-8674(92)90180-k. View

11.

Itoh N, Nagata S . A novel protein domain required for apoptosis. Mutational analysis of human Fas antigen. J Biol Chem. 1993; 268(15):10932-7. View

12.

Smith C, Gruss H, Davis T, Anderson D, Farrah T, Baker E . CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF. Cell. 1993; 73(7):1349-60. DOI: 10.1016/0092-8674(93)90361-s. View

13.

Ogasawara J, Adachi M, Matsuzawa A, Kasugai T, Kitamura Y, Itoh N . Lethal effect of the anti-Fas antibody in mice. Nature. 1993; 364(6440):806-9. DOI: 10.1038/364806a0. View

14.

Ellis T, Simms P, Slivnick D, Jack H, Fisher R . CD30 is a signal-transducing molecule that defines a subset of human activated CD45RO+ T cells. J Immunol. 1993; 151(5):2380-9. View

15.

Tartaglia L, Ayres T, Wong G, Goeddel D . A novel domain within the 55 kd TNF receptor signals cell death. Cell. 1993; 74(5):845-53. DOI: 10.1016/0092-8674(93)90464-2. View

16.

Pear W, Nolan G, Scott M, Baltimore D . Production of high-titer helper-free retroviruses by transient transfection. Proc Natl Acad Sci U S A. 1993; 90(18):8392-6. PMC: 47362. DOI: 10.1073/pnas.90.18.8392. View

17.

Gyuris J, Golemis E, Chertkov H, Brent R . Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2. Cell. 1993; 75(4):791-803. DOI: 10.1016/0092-8674(93)90498-f. View

18.

Smith C, Farrah T, Goodwin R . The TNF receptor superfamily of cellular and viral proteins: activation, costimulation, and death. Cell. 1994; 76(6):959-62. DOI: 10.1016/0092-8674(94)90372-7. View

19.

Gruss H, Boiani N, Williams D, Armitage R, Smith C, Goodwin R . Pleiotropic effects of the CD30 ligand on CD30-expressing cells and lymphoma cell lines. Blood. 1994; 83(8):2045-56. View

20.

Beutler B, Van Huffel C . Unraveling function in the TNF ligand and receptor families. Science. 1994; 264(5159):667-8. DOI: 10.1126/science.8171316. View