The Neurofibromatosis Type I Messenger RNA Undergoes Base-modification RNA Editing

Overview

Journal Nucleic Acids Res

Publisher Oxford University Press

Specialty Biochemistry

Date 1996 Feb 1

PMID 8602361

Citations 44

Authors

G R Skuse

A J Cappione

M Sowden

L J Metheny

H C Smith

Affiliations

Soon will be listed here.

Abstract

A functional mooring sequence, known to be required for apolipoprotein B (apoB) mRNA editing, exists in the mRNA encoding the neurofibromatosis type I (NF1) tumor suppressor. Editing of NF1 mRNA modifies cytidine in an arginine codon (CGA) at nucleotide 2914 to a uridine (UGA), creating an in frame translation stop codon. NF1 editing occurs in normal tissue but was several-fold higher in tumors. In vitro editing and transfection assays demonstrated that apoB and NF1 RNA editing will take place in both neural tumor and hepatoma cells. Unlike apoB, NF1 editing did not demonstrate dependence on rate-limiting quantities of APOBEC-1 (the apoB editing catalytic subunit) suggesting that different trans-acting factors may be involved in the two editing processes.

Citing Articles

RNA Editing in Cancer Progression.

Frezza V, Chellini L, Del Verme A, Paronetto M Cancers (Basel). 2023; 15(21).

PMID: 37958449 PMC: 10648226. DOI: 10.3390/cancers15215277.

DNA Deamination Is Required for Human APOBEC3A-Driven Hepatocellular Carcinoma In Vivo.

Naumann J, Argyris P, Carpenter M, Gupta H, Chen Y, Temiz N Int J Mol Sci. 2023; 24(11).

PMID: 37298259 PMC: 10253583. DOI: 10.3390/ijms24119305.

Mutagenic Activity of AID/APOBEC Deaminases in Antiviral Defense and Carcinogenesis.

Shilova O, Tsyba D, Shilov E Mol Biol. 2022; 56(1):46-58.

PMID: 35194245 PMC: 8852905. DOI: 10.1134/S002689332201006X.

APOBEC1 mediated C-to-U RNA editing: target sequence and trans-acting factor contribution to 177 RNA editing events in 119 murine transcripts in-vivo.

Soleymanjahi S, Blanc V, Davidson N RNA. 2021; .

PMID: 34083494 PMC: 8284327. DOI: 10.1261/rna.078678.121.

The effects of RNA editing in cancer tissue at different stages in carcinogenesis.

Kurkowiak M, Arcimowicz L, Chrusciel E, Urban-Wojciuk Z, Papak I, Keegan L RNA Biol. 2021; 18(11):1524-1539.

PMID: 33593231 PMC: 8582992. DOI: 10.1080/15476286.2021.1877024.

References

Cheng J, Maquat L . Nonsense codons can reduce the abundance of nuclear mRNA without affecting the abundance of pre-mRNA or the half-life of cytoplasmic mRNA. Mol Cell Biol. 1993; 13(3):1892-902. PMC: 359503. DOI: 10.1128/mcb.13.3.1892-1902.1993. View

Rueter S, Burns C, Coode S, Mookherjee P, Emeson R . Glutamate receptor RNA editing in vitro by enzymatic conversion of adenosine to inosine. Science. 1995; 267(5203):1491-4. DOI: 10.1126/science.7878468. View

Janke A, Paabo S . Editing of a tRNA anticodon in marsupial mitochondria changes its codon recognition. Nucleic Acids Res. 1993; 21(7):1523-5. PMC: 309357. DOI: 10.1093/nar/21.7.1523. View

Teng B, Burant C, Davidson N . Molecular cloning of an apolipoprotein B messenger RNA editing protein. Science. 1993; 260(5115):1816-9. DOI: 10.1126/science.8511591. View

Easton D, Ponder M, Huson S, Ponder B . An analysis of variation in expression of neurofibromatosis (NF) type 1 (NF1): evidence for modifying genes. Am J Hum Genet. 1993; 53(2):305-13. PMC: 1682337. View

Peltz S, Brown A, Jacobson A . mRNA destabilization triggered by premature translational termination depends on at least three cis-acting sequence elements and one trans-acting factor. Genes Dev. 1993; 7(9):1737-54. DOI: 10.1101/gad.7.9.1737. View

Navaratnam N, MORRISON J, Bhattacharya S, Patel D, Funahashi T, Giannoni F . The p27 catalytic subunit of the apolipoprotein B mRNA editing enzyme is a cytidine deaminase. J Biol Chem. 1993; 268(28):20709-12. View

Driscoll D, Oleksa L, Martinez D . Induction of RNA editing at heterologous sites by sequences in apolipoprotein B mRNA. Mol Cell Biol. 1993; 13(12):7288-94. PMC: 364799. DOI: 10.1128/mcb.13.12.7288-7294.1993. View

Higuchi M, Single F, Kohler M, Sommer B, Sprengel R, Seeburg P . RNA editing of AMPA receptor subunit GluR-B: a base-paired intron-exon structure determines position and efficiency. Cell. 1993; 75(7):1361-70. DOI: 10.1016/0092-8674(93)90622-w. View

10.

Backus J, Smith H . Specific 3' sequences flanking a minimal apolipoprotein B (apoB) mRNA editing 'cassette' are critical for efficient editing in vitro. Biochim Biophys Acta. 1994; 1217(1):65-73. View

11.

Herrick D, Ross J . The half-life of c-myc mRNA in growing and serum-stimulated cells: influence of the coding and 3' untranslated regions and role of ribosome translocation. Mol Cell Biol. 1994; 14(3):2119-28. PMC: 358572. DOI: 10.1128/mcb.14.3.2119-2128.1994. View

12.

Giannoni F, Bonen D, Funahashi T, Hadjiagapiou C, Burant C, Davidson N . Complementation of apolipoprotein B mRNA editing by human liver accompanied by secretion of apolipoprotein B48. J Biol Chem. 1994; 269(8):5932-6. View

13.

Driscoll D, Zhang Q . Expression and characterization of p27, the catalytic subunit of the apolipoprotein B mRNA editing enzyme. J Biol Chem. 1994; 269(31):19843-7. View

14.

Yamanaka S, Poksay K, Balestra M, Zeng G, Innerarity T . Cloning and mutagenesis of the rabbit ApoB mRNA editing protein. A zinc motif is essential for catalytic activity, and noncatalytic auxiliary factor(s) of the editing complex are widely distributed. J Biol Chem. 1994; 269(34):21725-34. View

15.

Belgrader P, Maquat L . Nonsense but not missense mutations can decrease the abundance of nuclear mRNA for the mouse major urinary protein, while both types of mutations can facilitate exon skipping. Mol Cell Biol. 1994; 14(9):6326-36. PMC: 359159. DOI: 10.1128/mcb.14.9.6326-6336.1994. View

16.

Backus J, Schock D, Smith H . Only cytidines 5' of the apolipoprotein B mRNA mooring sequence are edited. Biochim Biophys Acta. 1994; 1219(1):1-14. DOI: 10.1016/0167-4781(94)90240-2. View

17.

Sharma P, Bowman M, Madden S, Rauscher 3rd F, Sukumar S . RNA editing in the Wilms' tumor susceptibility gene, WT1. Genes Dev. 1994; 8(6):720-31. DOI: 10.1101/gad.8.6.720. View

18.

Knudson Jr A . Mutation and cancer: statistical study of retinoblastoma. Proc Natl Acad Sci U S A. 1971; 68(4):820-3. PMC: 389051. DOI: 10.1073/pnas.68.4.820. View

19.

SANGER F, Nicklen S, Coulson A . DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci U S A. 1977; 74(12):5463-7. PMC: 431765. DOI: 10.1073/pnas.74.12.5463. View

20.

Chomczynski P, Sacchi N . Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem. 1987; 162(1):156-9. DOI: 10.1006/abio.1987.9999. View