The Structure of the Escherichia Coli EF-Tu.EF-Ts Complex at 2.5 A Resolution

Overview

Journal Nature

Specialty Science

Date 1996 Feb 8

PMID 8596629

Citations 87

Authors

T Kawashima

C Berthet-Colominas

M Wulff

S Cusack

R Leberman

Affiliations

Soon will be listed here.

Abstract

The crystal structure of the EF-Tu.EF-Ts complex from Escherichia coli has been determined to a resolution of 2.5 A. The complex contains two subunits of each of the elongation factors. The two EF-Ts molecules form a tight dimer, but there is little contact between the two EF-Tu molecules. The interaction of EF-Ts with EF-Tu results principally in the disruption of the Mg2+ ion binding site, thereby reducing the affinity of EF-Tu for guanine nucleotides.

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