Increased Expression of Early Growth Response-1 Messenger Ribonucleic Acid in Prostatic Adenocarcinoma

Overview

Journal J Urol

Publisher Wolters Kluwer

Specialty Urology

Date 1996 Mar 1

PMID 8583621

Citations 20

Authors

A E Thigpen

K M Cala

J M Guileyardo

K H Molberg

J D McConnell

D W Russell

Affiliations

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Abstract

Purpose: We isolated genes whose expression differs between normal and malignant prostate.

Materials And Methods: Differential display polymerase chain reactions revealed a messenger ribonucleic acid (mRNA) with higher expression in prostatic adenocarcinoma versus age matched normal tissue. Deoxyribonucleic acid sequencing identified this mRNA as the product of the early growth response-1 gene.

Results: Early growth response-1 mRNA levels were elevated in 12 of 12 intraprostatic adenocarcinomas but not in breast or ovarian cancers, or in rapidly dividing rat ventral prostate cells. Early growth response-1 mRNA was detected in epithelial and stromal cells at tumor margins but not in lymph node metastases.

Conclusions: Early growth response-1, a nuclear transcription factor, is implicated in the growth and invasion of intraprostatic cancers.

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