Effect of Degree of Weight Loss on Health Benefits

Overview

Journal Obes Res

Specialties Endocrinology
Nutritional Sciences
Physiology

Date 1995 Sep 1

PMID 8581779

Citations 172

Authors

G Blackburn

Affiliations

Soon will be listed here.

Abstract

Although most dieters strive to achieve "ideal" body weight, clinical and laboratory evidence clearly supports the value of a modest weight loss goal to attain health and emotional benefit. Weight loss as low as 5% has been shown to reduce or eliminate disorders associated with obesity, though several questions remain partially or completely unanswered regarding the roles of degree of weight loss, method of weight loss, distribution of fat reduction, and other variables. This paper reviews the effect of degree of weight loss on specific disease states and risk factors and discusses the impact of ethnic background, fat distribution, age, and mode of weight loss on outcome.

Citing Articles

Unveiling the Therapeutic Potential of the Second-Generation Incretin Analogs Semaglutide and Tirzepatide in Type 1 Diabetes and Latent Autoimmune Diabetes in Adults.

Infante M, Silvestri F, Padilla N, Pacifici F, Pastore D, Pinheiro M J Clin Med. 2025; 14(4).

PMID: 40004833 PMC: 11856673. DOI: 10.3390/jcm14041303.

A Very Low-Carbohydrate Program in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease and Phospholipase Domain-Containing Protein 3 Risk Genotype: Pre-Post Intervention Study.

Saslow L, Krinock J, OBrien A, Raymond K, Bayandorian H, Moskowitz J JMIR Form Res. 2025; 9():e60051.

PMID: 39801107 PMC: 11740387. DOI: 10.2196/60051.

Subcutaneous weekly semaglutide with automated insulin delivery in type 1 diabetes: a double-blind, randomized, crossover trial.

Pasqua M, Tsoukas M, Kobayati A, Aboznadah W, Jafar A, Haidar A Nat Med. 2025; .

PMID: 39794615 DOI: 10.1038/s41591-024-03463-z.

Weight cycling exacerbates glucose intolerance and hepatic triglyceride storage in mice with a history of chronic high fat diet exposure.

Bernecker M, Lin A, Feuchtinger A, Molenaar A, Schriever S, Pfluger P J Transl Med. 2025; 23(1):7.

PMID: 39754229 PMC: 11699648. DOI: 10.1186/s12967-024-06039-0.

Prediction of individual weight loss using supervised learning: findings from the CALERIE 2 study.

Glasbrenner C, Hochsmann C, Pieper C, Wasserfurth P, Dorling J, Martin C Am J Clin Nutr. 2024; 120(5):1233-1244.

PMID: 39270937 PMC: 11600119. DOI: 10.1016/j.ajcnut.2024.09.003.