Prevalence of Borna Disease Virus RNA in Peripheral Blood Mononuclear Cells from Blood Donors

Overview

Journal Med Microbiol Immunol

Specialty Allergy & Immunology

Date 1995 Oct 1

PMID 8577314

Citations 19

Authors

M Kishi

T Nakaya

Y Nakamura

M Kakinuma

T A Takahashi

S Sekiguchi

M Uchikawa

K Tadokoro

K Ikeda

K Ikuta

Affiliations

Soon will be listed here.

Abstract

The presence of Borna disease virus (BDV) in peripheral blood mononuclear cells (PBMC) of 100 blood donors from Sapporo and 72 blood donors from Tokyo was examined using nested reverse transcriptase/polymerase chain reaction amplification with specific-primers for BDV p24. Anti-BDV p24 antibodies in the plasma of the 100 blood donors from Sapporo also were studied by enzyme-linked immunosorbent assay and by Western blot. BDV RNA was detected in 3 (4.2%) of the 72 PBMC samples from Tokyo, and in 5 (5%) of the 100 PBMC samples from Sapporo. In contrast, anti-p24 antibodies were found in only 1 (1%) of the donors from Sapporo. These results suggest that BDV infection in humans may be more widespread than previously thought.

Citing Articles

Sero-epidemiological analysis of vertical transmission relative risk of Borna disease virus infection in dairy herds.

Ando T, Takino T, Makita K, Tajima M, Koiwa M, Hagiwara K J Vet Med Sci. 2016; 78(11):1669-1672.

PMID: 27498995 PMC: 5138419. DOI: 10.1292/jvms.16-0156.

Evidence for Borna disease virus infection in neuropsychiatric patients in three western China provinces.

Zhang L, Xu M, Zeng L, Liu S, Liu X, Wang X Eur J Clin Microbiol Infect Dis. 2013; 33(4):621-7.

PMID: 24170181 DOI: 10.1007/s10096-013-1996-4.

Absence of evidence for bornavirus infection in schizophrenia, bipolar disorder and major depressive disorder.

Hornig M, Briese T, Licinio J, Khabbaz R, Altshuler L, Potkin S Mol Psychiatry. 2012; 17(5):486-93.

PMID: 22290118 PMC: 3622588. DOI: 10.1038/mp.2011.179.

Failure to detect borna disease virus antibody and RNA from peripheral blood mononuclear cells of psychiatric patients.

Na K, Tae S, Song J, Kim Y Psychiatry Investig. 2010; 6(4):306-12.

PMID: 20140130 PMC: 2808801. DOI: 10.4306/pi.2009.6.4.306.

Borna disease virus RNA detected in Japanese macaques (Macaca fuscata).

Hagiwara K, Tsuge Y, Asakawa M, Kabaya H, Okamoto M, Miyasho T Primates. 2007; 49(1):57-64.

PMID: 17929110 DOI: 10.1007/s10329-007-0068-8.

References

Kao M, Hamir A, Rupprecht C, Fu Z, Shankar V, KOPROWSKI H . Detection of antibodies against Borna disease virus in sera and cerebrospinal fluid of horses in the USA. Vet Rec. 1993; 132(10):241-4. DOI: 10.1136/vr.132.10.241. View

de la Torre J . Molecular biology of borna disease virus: prototype of a new group of animal viruses. J Virol. 1994; 68(12):7669-75. PMC: 237226. DOI: 10.1128/JVI.68.12.7669-7675.1994. View

Herzog S, Rott R . Replication of Borna disease virus in cell cultures. Med Microbiol Immunol. 1980; 168(3):153-8. DOI: 10.1007/BF02122849. View

Herzog S, Kompter C, Frese K, Rott R . Replication of Borna disease virus in rats: age-dependent differences in tissue distribution. Med Microbiol Immunol. 1984; 173(4):171-7. DOI: 10.1007/BF02122108. View

Schneider P, Briese T, Zimmermann W, Ludwig H, Lipkin W . Sequence conservation in field and experimental isolates of Borna disease virus. J Virol. 1994; 68(1):63-8. PMC: 236264. DOI: 10.1128/JVI.68.1.63-68.1994. View

Weiss S, Konig B, Morikawa Y, Jones I . Recombinant HIV-1 nucleocapsid protein p15 produced as a fusion protein with glutathione S-transferase in Escherichia coli mediates dimerization and enhances reverse transcription of retroviral RNA. Gene. 1992; 121(2):203-12. DOI: 10.1016/0378-1119(92)90123-7. View

Bode L, Zimmermann W, Ferszt R, Steinbach F, Ludwig H . Borna disease virus genome transcribed and expressed in psychiatric patients. Nat Med. 1995; 1(3):232-6. DOI: 10.1038/nm0395-232. View

Bode L, Riegel S, Ludwig H, Amsterdam J, Lange W, KOPROWSKI H . Borna disease virus-specific antibodies in patients with HIV infection and with mental disorders. Lancet. 1988; 2(8612):689. DOI: 10.1016/s0140-6736(88)90505-3. View

Kishi M, Nakaya T, Nakamura Y, Zhong Q, Ikeda K, Senjo M . Demonstration of human Borna disease virus RNA in human peripheral blood mononuclear cells. FEBS Lett. 1995; 364(3):293-7. DOI: 10.1016/0014-5793(95)00406-y. View

10.

Rott R, Herzog S, Fleischer B, Winokur A, Amsterdam J, Dyson W . Detection of serum antibodies to Borna disease virus in patients with psychiatric disorders. Science. 1985; 228(4700):755-6. DOI: 10.1126/science.3922055. View

11.

Bode L, Steinbach F, Ludwig H . A novel marker for Borna disease virus infection. Lancet. 1994; 343(8892):297-8. DOI: 10.1016/s0140-6736(94)91147-9. View

12.

Richt J, Herzog S, Pyper J, Clements J, Narayan O, Bechter K . Borna disease virus: nature of the etiologic agent and significance of infection in man. Arch Virol Suppl. 1993; 7:101-9. DOI: 10.1007/978-3-7091-9300-6_9. View

13.

Narayan O, Herzog S, Frese K, Scheefers H, Rott R . Behavioral disease in rats caused by immunopathological responses to persistent borna virus in the brain. Science. 1983; 220(4604):1401-3. DOI: 10.1126/science.6602380. View

14.

Rott R, Herzog S, Bechter K, Frese K . Borna disease, a possible hazard for man?. Arch Virol. 1991; 118(3-4):143-9. DOI: 10.1007/BF01314025. View

15.

Schneemann A, Schneider P, Lamb R, Lipkin W . The remarkable coding strategy of borna disease virus: a new member of the nonsegmented negative strand RNA viruses. Virology. 1995; 210(1):1-8. DOI: 10.1006/viro.1995.1311. View

16.

Zimmermann W, Durrwald R, Ludwig H . Detection of Borna disease virus RNA in naturally infected animals by a nested polymerase chain reaction. J Virol Methods. 1994; 46(2):133-43. DOI: 10.1016/0166-0934(94)90098-1. View

17.

Rubin S, Estafanous M, Yolken R, Carbone K . Borna disease virus in peripheral blood mononuclear and bone marrow cells of neonatally and chronically infected rats. J Neuroimmunol. 1993; 45(1-2):31-6. DOI: 10.1016/0165-5728(93)90160-z. View

18.

Nakamura Y, Kishi M, Nakaya T, Asahi S, Tanaka H, Sentsui H . Demonstration of Borna disease virus RNA in peripheral blood mononuclear cells from healthy horses in Japan. Vaccine. 1995; 13(12):1076-9. DOI: 10.1016/0264-410x(95)00050-b. View

19.

Bode L, Ferszt R, Czech G . Borna disease virus infection and affective disorders in man. Arch Virol Suppl. 1993; 7:159-67. DOI: 10.1007/978-3-7091-9300-6_13. View

20.

Cubitt B, Oldstone C, de la Torre J . Sequence and genome organization of Borna disease virus. J Virol. 1994; 68(3):1382-96. PMC: 236592. DOI: 10.1128/JVI.68.3.1382-1396.1994. View