Borna Disease, a Possible Hazard for Man?

Overview

Journal Arch Virol

Specialty Microbiology

Date 1991 Jan 1

PMID 2069502

Citations 33

Authors

R Rott

S Herzog

K Bechter

K Frese

Affiliations

Soon will be listed here.

Abstract

Evidence is presented that Borna disease (BD) virus, which is known to cause encephalopathy in horses, sheep, and a broad range of experimental animals, or a related agent, can infect man and may induce mental disorders. BD virus-specific antibodies could be demonstrated in 4-7% of sera (depending on origin) from more than 5000 psychiatric or neurological patients from Germany, U.S.A. and Japan. Antibodies from seropositive patients reacted with a BD virus-specific protein translated by RNAs which were transcribed from a cDNA clone obtained from BD virus-infected tissues. When the cerebrospinal fluid from three seropositive patients was inoculated into rabbits or rabbit embryonic brain cell cultures, evidence was obtained that suggests the presence of BD virus or a related agent.

Citing Articles

The Challenge of Assessing Mild Neuroinflammation in Severe Mental Disorders.

Bechter K Front Psychiatry. 2020; 11:773.

PMID: 32973573 PMC: 7469926. DOI: 10.3389/fpsyt.2020.00773.

[Rabies and Bornavirus encephalitis : Fatal emerging viral encephalitis-a potential problem for organ recipients].

Schmutzhard E, Pfausler B Nervenarzt. 2018; 89(12):1332-1337.

PMID: 30276429 DOI: 10.1007/s00115-018-0620-3.

Borna disease virus RNA in immunocompromised patients in southwestern France.

Cotto E, Neau D, Cransac-Neau M, Auriacombe M, Pellegrin J, Ragnaud J J Clin Microbiol. 2003; 41(12):5577-81.

PMID: 14662943 PMC: 308971. DOI: 10.1128/JCM.41.12.5577-5581.2003.

Borna disease virus.

Hornig M, Briese T, Lipkin W J Neurovirol. 2003; 9(2):259-73.

PMID: 12707857 DOI: 10.1080/13550280390194064.

Borna disease virus and human disease.

Carbone K Clin Microbiol Rev. 2001; 14(3):513-27.

PMID: 11432811 PMC: 88987. DOI: 10.1128/CMR.14.3.513-527.2001.

References

Ludwig H, Bode L, Gosztonyi G . Borna disease: a persistent virus infection of the central nervous system. Prog Med Virol. 1988; 35:107-51. View

Ludwig H, Koester V, Pauli G, Rott R . The cerebrospinal fluid of rabbits infected with Borna disease virus. Arch Virol. 1977; 55(3):209-23. DOI: 10.1007/BF01319907. View

Herzog S, Rott R . Replication of Borna disease virus in cell cultures. Med Microbiol Immunol. 1980; 168(3):153-8. DOI: 10.1007/BF02122849. View

Herzog S, Kompter C, Frese K, Rott R . Replication of Borna disease virus in rats: age-dependent differences in tissue distribution. Med Microbiol Immunol. 1984; 173(4):171-7. DOI: 10.1007/BF02122108. View

KREY H, Ludwig H, Rott R . Spread of infectious virus along the optic nerve into the retina in Borna disease virus-infected rabbits. Arch Virol. 1979; 61(4):283-8. DOI: 10.1007/BF01315014. View

Richt J, Stitz L, Wekerle H, Rott R . Borna disease, a progressive meningoencephalomyelitis as a model for CD4+ T cell-mediated immunopathology in the brain. J Exp Med. 1989; 170(3):1045-50. PMC: 2189432. DOI: 10.1084/jem.170.3.1045. View

Gosztonyi G, Ludwig H . Borna disease of horses. An immunohistological and virological study of naturally infected animals. Acta Neuropathol. 1984; 64(3):213-21. DOI: 10.1007/BF00688111. View

Duchala C, Carbone K, Narayan O . Preliminary studies on the biology of Borna disease virus. J Gen Virol. 1989; 70 ( Pt 12):3507-11. DOI: 10.1099/0022-1317-70-12-3507. View

Narayan O, Herzog S, Frese K, Scheefers H, Rott R . Pathogenesis of Borna disease in rats: immune-mediated viral ophthalmoencephalopathy causing blindness and behavioral abnormalities. J Infect Dis. 1983; 148(2):305-15. DOI: 10.1093/infdis/148.2.305. View

10.

Rott R, Herzog S, Fleischer B, Winokur A, Amsterdam J, Dyson W . Detection of serum antibodies to Borna disease virus in patients with psychiatric disorders. Science. 1985; 228(4700):755-6. DOI: 10.1126/science.3922055. View

11.

Stitz L, Soeder D, Deschl U, Frese K, Rott R . Inhibition of immune-mediated meningoencephalitis in persistently Borna disease virus-infected rats by cyclosporine A. J Immunol. 1989; 143(12):4250-6. View

12.

Deschl U, Stitz L, Herzog S, Frese K, Rott R . Determination of immune cells and expression of major histocompatibility complex class II antigen in encephalitic lesions of experimental Borna disease. Acta Neuropathol. 1990; 81(1):41-50. DOI: 10.1007/BF00662636. View

13.

Hirano N, Kao M, Ludwig H . Persistent, tolerant or subacute infection in Borna disease virus-infected rats. J Gen Virol. 1983; 64 (Pt 7):1521-30. DOI: 10.1099/0022-1317-64-7-1521. View

14.

Morales J, Herzog S, Kompter C, Frese K, Rott R . Axonal transport of Borna disease virus along olfactory pathways in spontaneously and experimentally infected rats. Med Microbiol Immunol. 1988; 177(2):51-68. DOI: 10.1007/BF00189527. View

15.

Lipkin W, Travis G, Carbone K, Wilson M . Isolation and characterization of Borna disease agent cDNA clones. Proc Natl Acad Sci U S A. 1990; 87(11):4184-8. PMC: 54072. DOI: 10.1073/pnas.87.11.4184. View

16.

Narayan O, Herzog S, Frese K, Scheefers H, Rott R . Behavioral disease in rats caused by immunopathological responses to persistent borna virus in the brain. Science. 1983; 220(4604):1401-3. DOI: 10.1126/science.6602380. View

17.

Herzog S, Wonigeit K, Frese K, Hedrich H, Rott R . Effect of Borna disease virus infection on athymic rats. J Gen Virol. 1985; 66 ( Pt 3):503-8. DOI: 10.1099/0022-1317-66-3-503. View

18.

Vandewoude S, Richt J, Zink M, Rott R, Narayan O, Clements J . A borna virus cDNA encoding a protein recognized by antibodies in humans with behavioral diseases. Science. 1990; 250(4985):1278-81. DOI: 10.1126/science.2244211. View

19.

Carbone K, Duchala C, Griffin J, Kincaid A, Narayan O . Pathogenesis of Borna disease in rats: evidence that intra-axonal spread is the major route for virus dissemination and the determinant for disease incubation. J Virol. 1987; 61(11):3431-40. PMC: 255939. DOI: 10.1128/JVI.61.11.3431-3440.1987. View

20.

Amsterdam J, Winokur A, Dyson W, Herzog S, Gonzalez F, Rott R . Borna disease virus. A possible etiologic factor in human affective disorders?. Arch Gen Psychiatry. 1985; 42(11):1093-6. DOI: 10.1001/archpsyc.1985.01790340077011. View