Nitric Oxide Donors: Biochemical Pharmacology and Therapeutics
Overview
Affiliations
The NO donors are a diverse group of agents with unique chemical structures and biochemical requirements for generation of NO. The differences in biochemistry and metabolism may, in turn, cause differences in their pharmacology and therapeutic actions. A thorough understanding of the biochemical pharmacology of NO donors and factors controlling their therapeutic activity would facilitate the optimal use of these agents as chemical carriers of NO, and the development of newer agents than can selectively modulate the many physiological actions of NO.
A novel anti-epileptogenesis strategy of temporal lobe epilepsy based on nitric oxide donor.
Zhu X, Zhou Y, Zhang Q, Zhu M, Song X, Li J EMBO Mol Med. 2024; 17(1):85-111.
PMID: 39653809 PMC: 11730642. DOI: 10.1038/s44321-024-00168-1.
Li L, Lin Z, Lu X, Chen C, Xie A, Tang Y RSC Adv. 2022; 12(51):33358-33364.
PMID: 36506481 PMC: 9686666. DOI: 10.1039/d2ra05352g.
Endothelial dysfunction and body mass index: is there a role for plasma peroxynitrite?.
Chikopela T, Heimburger D, Kaluba L, Hamambulu P, Simfukwe N, Mutale W Beni Suef Univ J Basic Appl Sci. 2021; 10(1).
PMID: 33569505 PMC: 7872153. DOI: 10.1186/s43088-020-00092-6.
Nitric oxide modulators: an emerging class of medicinal agents.
Deshpande S, Satyanarayana K, Rao M, Pai K Indian J Pharm Sci. 2013; 74(6):487-97.
PMID: 23798773 PMC: 3687917. DOI: 10.4103/0250-474X.110572.
Nitrates and nitrites in the treatment of ischemic cardiac disease.
Nossaman V, Nossaman B, Kadowitz P Cardiol Rev. 2010; 18(4):190-7.
PMID: 20539102 PMC: 2885014. DOI: 10.1097/CRD.0b013e3181c8e14a.