Principles of Protein-protein Interactions

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1996 Jan 9

PMID 8552589

Citations 821

Authors

S Jones

J M Thornton

Affiliations

Soon will be listed here.

Abstract

This review examines protein complexes in the Brookhaven Protein Databank to gain a better understanding of the principles governing the interactions involved in protein-protein recognition. The factors that influence the formation of protein-protein complexes are explored in four different types of protein-protein complexes--homodimeric proteins, heterodimeric proteins, enzyme-inhibitor complexes, and antibody-protein complexes. The comparison between the complexes highlights differences that reflect their biological roles.

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