Frur Mediates Catabolite Activation of Pyruvate Kinase (pykF) Gene Expression in Escherichia Coli

Overview

Journal J Bacteriol

Publisher American Society for Microbiology

Specialty Microbiology

Date 1996 Jan 1

PMID 8550429

Citations 31

Authors

S A Bledig

T M Ramseier

M H Saier Jr

Affiliations

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Abstract

Expression of a pykF-lacZ fusion was studied as a function of the carbon source in wild-type strains and strains lacking or overproducing the FruR protein of Escherichia coli. FruR controls the response to the carbon source by repressing pykF expression more strongly under gluconeogenic than under glycolytic conditions, a phenomenon we term catabolite activation.

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