Ciprofloxacin for Treatment of Severe Typhoid Fever in Children

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 1993 May 1

PMID 8517716

Citations 13

Authors

P Dutta

R Rasaily

M R Saha

U Mitra

S K Bhattacharya

M K Bhattacharya

M Lahiri

Affiliations

Soon will be listed here.

Abstract

Eighteen children with bacteriologically confirmed severe typhoid fever were initially treated intravenously with ciprofloxacin (10 mg/kg of body weight per day). Clinical cure with eradication of multiresistant Salmonella typhi infection was observed in 17 patients (94.4%; 95% confidence interval [CI], 84 to 100%). Children regained normal consciousness within an average of 2 days (95% CI, 1.8 to 2.2 days). The temperatures of the children returned to normal within 3.3 days (95% CI, 3.1 to 3.5 days). Complications were not observed during the hospital stay or a 3-month follow-up period. Relapse and carrier state were also not encountered during the follow-up period.

Citing Articles

Safety of Quinolones in Children: A Systematic Review and Meta-Analysis.

Li S, Chen Z, Huang L, Liu Z, Shi Y, Zhang M Paediatr Drugs. 2022; 24(5):447-464.

PMID: 35771411 DOI: 10.1007/s40272-022-00513-2.

Prevalence and antimicrobial susceptibility patterns of and isolates among children aged below five years with diarrhea attending Robe General Hospital and Goba Referral Hospital, South East Ethiopia.

Assefa A, Girma M Trop Dis Travel Med Vaccines. 2019; 5:19.

PMID: 31832223 PMC: 6864936. DOI: 10.1186/s40794-019-0096-6.

Ciprofloxacin safety in paediatrics: a systematic review.

Adefurin A, Sammons H, Jacqz-Aigrain E, Choonara I Arch Dis Child. 2011; 96(9):874-80.

PMID: 21785119 PMC: 3155117. DOI: 10.1136/adc.2010.208843.

An imported enteric fever caused by a quinolone-resistant Salmonella Typhi.

Somily A Ann Saudi Med. 2010; 30(4):313-6.

PMID: 20622350 PMC: 2931784. DOI: 10.4103/0256-4947.65267.

Modification of enrofloxacin treatment regimens for poultry experimentally infected with Salmonella enterica serovar Typhimurium DT104 to minimize selection of resistance.

Randall L, Cooles S, Coldham N, Stapleton K, Piddock L, Woodward M Antimicrob Agents Chemother. 2006; 50(12):4030-7.

PMID: 17030564 PMC: 1694010. DOI: 10.1128/AAC.00525-06.

References

Edelman R, Levine M . Summary of an international workshop on typhoid fever. Rev Infect Dis. 1986; 8(3):329-49. DOI: 10.1093/clinids/8.3.329. View

Pape J, Gerdes H, Oriol L, Johnson Jr W . Typhoid fever: successful therapy with cefoperazone. J Infect Dis. 1986; 153(2):272-6. DOI: 10.1093/infdis/153.2.272. View

Mandal B, Flegg P, Dunbar E, Whale K, Brennand J . Ciprofloxacin in enteric fever. Chemioterapia. 1987; 6(2 Suppl):492-3. View

Adam D . Use of quinolones in pediatric patients. Rev Infect Dis. 1989; 11 Suppl 5:S1113-6. DOI: 10.1093/clinids/11.supplement_5.s1113. View

Anand A, Kataria V, Singh W, Chatterjee S . Epidemic multiresistant enteric fever in eastern India. Lancet. 1990; 335(8685):352. DOI: 10.1016/0140-6736(90)90635-i. View

Rogerson S, Spooner V, Smith T, Richens J . Hydrocortisone in chloramphenicol-treated severe typhoid fever in Papua New Guinea. Trans R Soc Trop Med Hyg. 1991; 85(1):113-6. DOI: 10.1016/0035-9203(91)90180-7. View

Sen S, Goyal R, Dev R . Ciprofloxacin in the management of multiple drug resistant typhoid fever. Indian Pediatr. 1991; 28(4):417-9. View

Saha M, Dutta P, Bhattacharya S, Rasaily R, Mitra U, Dutta D . Occurrence of multi-drug resistant Salmonella typhi in Calcutta. Indian J Med Res. 1992; 95:179-80. View

BAUER A, KIRBY W, SHERRIS J, Turck M . Antibiotic susceptibility testing by a standardized single disk method. Am J Clin Pathol. 1966; 45(4):493-6. View

10.

GULATI P, Saxena S, Gupta P, Chuttani H . Changing pattern of typhoid fever. Am J Med. 1968; 45(4):544-8. DOI: 10.1016/0002-9343(68)90170-8. View

11.

Duggan M, Beyer L . Enteric fever in young Yoruba children. Arch Dis Child. 1975; 50(1):67-71. PMC: 1544475. DOI: 10.1136/adc.50.1.67. View

12.

Johnson A, Aderele W . Enteric fever in childhood. J Trop Med Hyg. 1981; 84(1):29-35. View

13.

Butler T, Rumans L, Arnold K . Response of typhoid fever caused by chloramphenicol-susceptible and chloramphenicol-resistant strains of Salmonella typhi to treatment with trimethoprim-sulfamethoxazole. Rev Infect Dis. 1982; 4(2):551-61. DOI: 10.1093/clinids/4.2.551. View

14.

Hoffman S, Punjabi N, Kumala S, Moechtar M, Pulungsih S, Rivai A . Reduction of mortality in chloramphenicol-treated severe typhoid fever by high-dose dexamethasone. N Engl J Med. 1984; 310(2):82-8. DOI: 10.1056/NEJM198401123100203. View

15.

McClain J, RHOADS J, Krol G . Cerebrospinal fluid concentrations of ciprofloxacin in subjects with uninflamed meninges. J Antimicrob Chemother. 1988; 21(6):808-9. DOI: 10.1093/jac/21.6.808. View