In Vitro Activities of New Macrolides and Rifapentine Against Brucella Spp

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 1993 Apr 1

PMID 8494391

Citations 9

Authors

J A Garcia-Rodriguez

J L Munoz Bellido

M J Fresnadillo

I Trujillano

Affiliations

Soon will be listed here.

Abstract

We have tested the in vitro activities of streptomycin, rifampin, tetracyclines, trimethoprim-sulfamethoxazole, erythromycin, four new macrolides (roxithromycin, azithromycin, clarithromycin, and dirithromycin), and rifapentine against 62 strains of Brucella spp. Azithromycin and clarithromycin were, respectively, eight- and twofold more active than erythromycins (MIC for 90% of strains = 2, 8, and 16 micrograms/ml, respectively). The activity of rifapentine was similar to that of rifampin (MIC for 90% of strains = 1 microgram/ml).

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