An Interspecies Idiotope Associated with the Anti-cholera Toxin Response Detected by a Monoclonal Auto-anti-idiotypic Antibody

Overview

Journal Immunology

Specialty Allergy & Immunology

Date 1993 Mar 1

PMID 8478032

Citations 1

Authors

G P Lucas

C L Cambiaso

J P Vaerman

Affiliations

Soon will be listed here.

Abstract

We have produced an auto-anti-idiotypic (auto-anti-id) monoclonal antibody (mAb) which reacted with syngenic mouse polyclonal anti-cholera toxin (anti-CT) IgG antibody (Ab) and six/eight different anti-CT IgG mAb, but not with normal mouse BALB/c IgG. The binding of this auto-anti-id mAb on one anti-CT mAb was significantly inhibited by polyclonal anti-CT sera of rats, rabbits and mice. Thus the idiotope on anti-CT Ab recognized by this auto-anti-id mAb was public and expressed in different species. Because of the absence of competition between CT and this auto-anti-id mAb for the binding to the six anti-CT mAb, the anti-id mAb was classified as an Ab2 alpha. The efficiency of this auto-anti-id mAb to induce anti-CT Ab3 was tested with success in rabbits and rats. Auto-anti-id mAb-immunized rats were significantly protected against an intraintestinal CT challenge.

Citing Articles

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Magliani W, Conti S, Gerloni M, Bertolotti D, Polonelli L Clin Microbiol Rev. 1997; 10(3):369-400.

PMID: 9227858 PMC: 172926. DOI: 10.1128/CMR.10.3.369.

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