Expression of Members of the Heat-shock Protein 70 Family in the Exoerythrocytic Stages of Plasmodium Berghei and Plasmodium Falciparum

Overview

Journal Parasitol Res

Specialty Parasitology

Date 1993 Jan 1

PMID 8475027

Citations 8

Authors

N Kumar

H Nagasawa

J B Sacci Jr

B J Sina

M Aikawa

C Atkinson

P Uparanukraw

L B Kubiak

A F Azad

M R Hollingdale

Affiliations

Soon will be listed here.

Abstract

Exoerythrocytic stages of Plasmodium berghei cultured in HepG2-A16 hepatoma cells and those of P. falciparum in human hepatocytes transplanted under the kidney capsule of CB-17/ICr scid/scid mice were used to evaluate expression of heat-shock-related stress proteins. Although undetectable in the sporozoites, the expression of proteins similar in sequence of a heat-shock protein of 70 kDa and a glucose-regulated protein of 78 kDa was markedly induced in the hepatic stages of malaria parasites. Expression of these proteins in the exoerythrocytic stages of the malaria parasite warrants a systematic evaluation of their potential role in eliciting cellular immune responses directed against infected hepatocytes.

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