Biochemical Markers of Nutrition in Osteoporosis
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Thirty-six women with vertebral osteoporosis showed significantly decreased levels of biochemical markers of nutrition, transferrin (P < 0.001), prealbumin (P < 0.001), retinol binding-protein (P < 0.001), and fibronectin (P < 0.001), compared with 40 healthy women of similar age. Multiple regression analysis showed a significant (R2 = 0.509; P = 0.0068) correlation between bone mineral content and biochemical markers of nutrition in the osteoporotic patients but not in the control group. These data suggest that postmenopausal osteoporosis may be associated with a nutritional deficiency.
Reduction of dietary magnesium by only 50% in the rat disrupts bone and mineral metabolism.
Rude R, Gruber H, Norton H, Wei L, Frausto A, Kilburn J Osteoporos Int. 2006; 17(7):1022-32.
PMID: 16601920 DOI: 10.1007/s00198-006-0104-3.
Vertebral and metacarpal morphometry as indicators of nutritional improvement.
Revilla M, Fraile E, Aguado F, Hermandez E, Villa L, Rico H Clin Rheumatol. 1997; 16(3):279-83.
PMID: 9184266 DOI: 10.1007/BF02238964.