The Use of Magnetic Resonance Imaging to Track Controlled Drug Release and Transport in the Brain

Overview

Journal Magn Reson Imaging

Publisher Elsevier

Specialty Radiology

Date 1993 Jan 1

PMID 8455434

Citations 4

Authors

B Reisfeld

S Blackband

V Calhoun

S Grossman

S Eller

K Leong

Affiliations

Soon will be listed here.

Abstract

A method has been developed to track controlled drug release and transport in the brain. This method entails the use of a polymeric implant to release, over time, a paramagnetically labelled compound into the brain. Magnetic resonance imaging is used to determine the evolving concentration distribution. This method is well suited to other types of intracranial drug delivery systems as well as to track transport in other organs of the body.

Citing Articles

Biomedical Imaging in Implantable Drug Delivery Systems.

Zhou H, Hernandez C, Goss M, Gawlik A, Exner A Curr Drug Targets. 2014; 16(6):672-82.

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Drug elimination kinetics following subconjunctival injection using dynamic contrast-enhanced magnetic resonance imaging.

Kim S, Csaky K, Wang N, Lutz R Pharm Res. 2007; 25(3):512-20.

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Localized delivery of proteins in the brain: can transport be customized?.

Haller M, Saltzman W Pharm Res. 1998; 15(3):377-85.

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In vitro/in vivo comparison of drug release and polymer erosion from biodegradable P(FAD-SA) polyanhydrides--a noninvasive approach by the combined use of electron paramagnetic resonance spectroscopy and nuclear magnetic resonance imaging.

Mader K, Cremmilleux Y, Domb A, Dunn J, Swartz H Pharm Res. 1997; 14(6):820-6.

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